TY - JOUR
T1 - Shaping the future of antiviral Treatment
T2 - Spotlight on Nucleobase-Containing drugs and their revolutionary impact
AU - Wong, Xi Khai
AU - Ng, Chen Seng
AU - Yeong, Keng Yoon
N1 - Funding Information:
The authors acknowledge the School of Science, Monash University Malaysia for supporting this work. Xi Khai Wong is supported by the Graduate Research Excellence Scholarship from Monash University Malaysia .
Publisher Copyright:
© 2024 The Author(s)
PY - 2024/3
Y1 - 2024/3
N2 - Nucleobases serve as essential molecular frameworks present in both natural and synthetic compounds that exhibit notable antiviral activity. Through molecular modifications, novel nucleobase-containing drugs (NCDs) have been developed, exhibiting enhanced antiviral activity against a wide range of viruses, including the recently emerged SARS‑CoV‑2. This article provides a detailed examination of the significant advancements in NCDs from 2015 till current, encompassing various aspects concerning their mechanisms of action, pharmacology and antiviral properties. Additionally, the article discusses antiviral prodrugs relevant to the scope of this review. It fills in the knowledge gap by examining the structure–activity relationship and trend of NCDs as therapeutics against a diverse range of viral diseases, either as approved drugs, clinical candidates or as early-stage development prospects. Moreover, the article highlights on the status of this field of study and addresses the prevailing limitations encountered.
AB - Nucleobases serve as essential molecular frameworks present in both natural and synthetic compounds that exhibit notable antiviral activity. Through molecular modifications, novel nucleobase-containing drugs (NCDs) have been developed, exhibiting enhanced antiviral activity against a wide range of viruses, including the recently emerged SARS‑CoV‑2. This article provides a detailed examination of the significant advancements in NCDs from 2015 till current, encompassing various aspects concerning their mechanisms of action, pharmacology and antiviral properties. Additionally, the article discusses antiviral prodrugs relevant to the scope of this review. It fills in the knowledge gap by examining the structure–activity relationship and trend of NCDs as therapeutics against a diverse range of viral diseases, either as approved drugs, clinical candidates or as early-stage development prospects. Moreover, the article highlights on the status of this field of study and addresses the prevailing limitations encountered.
KW - Analogue
KW - Antiviral
KW - Nucleobase
KW - Nucleoside
KW - Nucleotide
KW - Structure-activity relationship
UR - https://www.scopus.com/pages/publications/85185226188
U2 - 10.1016/j.bioorg.2024.107150
DO - 10.1016/j.bioorg.2024.107150
M3 - Review Article
C2 - 38309002
AN - SCOPUS:85185226188
SN - 0045-2068
VL - 144
JO - Bioorganic Chemistry
JF - Bioorganic Chemistry
M1 - 107150
ER -