Sexually transmitted infections: Challenges ahead

Magnus Unemo, Catriona S. Bradshaw, Jane S. Hocking, Henry J.C. de Vries, Suzanna C. Francis, David C Mabey, Jeanne M. Marrazzo, Gerard J.B. Sonder, Jane R. Schwebke, Elske Hoornenborg, Rosanna W. Peeling, Susan S. Philip, Nicola Low, Christopher K. Fairley

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

WHO estimated that nearly 1 million people become infected every day with any of four curable sexually transmitted infections (STIs): chlamydia, gonorrhoea, syphilis, and trichomoniasis. Despite their high global incidence, STIs remain a neglected area of research. In this Commission, we have prioritised five areas that represent particular challenges in STI treatment and control. Chlamydia remains the most commonly diagnosed bacterial STI in high-income countries despite widespread testing recommendations, sensitive and specific non-invasive testing techniques, and cheap effective therapy. We discuss the challenges for chlamydia control and evidence to support a shift from the current focus on infection-based screening to improved management of diagnosed cases and of chlamydial morbidity, such as pelvic inflammatory disease. The emergence and spread of antimicrobial resistance in Neisseria gonorrhoeae is globally recognised. We review current and potential future control and treatment strategies, with a focus on novel antimicrobials. Bacterial vaginosis is the most common vaginal disorder in women, but current treatments are associated with frequent recurrence. Recurrence after treatment might relate to evidence that suggests sexual transmission is integral to the pathogenesis of bacterial vaginosis, which has substantial implications for the development of effective management approaches. STIs disproportionately affect low-income and middle-income countries. We review strategies for case management, focusing on point-of-care tests that hold considerable potential for improving STI control. Lastly, STIs in men who have sex with men have increased since the late 1990s. We discuss the contribution of new biomedical HIV prevention strategies and risk compensation. Overall, this Commission aims to enhance the understanding of some of the key challenges facing the field of STIs, and outlines new approaches to improve the clinical management of STIs and public health.

Original languageEnglish
Pages (from-to)e235-e279
Number of pages45
JournalLancet Infectious Diseases
Volume17
Issue number8
DOIs
Publication statusPublished - Aug 2017

Cite this

Unemo, M., Bradshaw, C. S., Hocking, J. S., de Vries, H. J. C., Francis, S. C., Mabey, D. C., ... Fairley, C. K. (2017). Sexually transmitted infections: Challenges ahead. Lancet Infectious Diseases, 17(8), e235-e279. https://doi.org/10.1016/S1473-3099(17)30310-9
Unemo, Magnus ; Bradshaw, Catriona S. ; Hocking, Jane S. ; de Vries, Henry J.C. ; Francis, Suzanna C. ; Mabey, David C ; Marrazzo, Jeanne M. ; Sonder, Gerard J.B. ; Schwebke, Jane R. ; Hoornenborg, Elske ; Peeling, Rosanna W. ; Philip, Susan S. ; Low, Nicola ; Fairley, Christopher K. / Sexually transmitted infections : Challenges ahead. In: Lancet Infectious Diseases. 2017 ; Vol. 17, No. 8. pp. e235-e279.
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abstract = "WHO estimated that nearly 1 million people become infected every day with any of four curable sexually transmitted infections (STIs): chlamydia, gonorrhoea, syphilis, and trichomoniasis. Despite their high global incidence, STIs remain a neglected area of research. In this Commission, we have prioritised five areas that represent particular challenges in STI treatment and control. Chlamydia remains the most commonly diagnosed bacterial STI in high-income countries despite widespread testing recommendations, sensitive and specific non-invasive testing techniques, and cheap effective therapy. We discuss the challenges for chlamydia control and evidence to support a shift from the current focus on infection-based screening to improved management of diagnosed cases and of chlamydial morbidity, such as pelvic inflammatory disease. The emergence and spread of antimicrobial resistance in Neisseria gonorrhoeae is globally recognised. We review current and potential future control and treatment strategies, with a focus on novel antimicrobials. Bacterial vaginosis is the most common vaginal disorder in women, but current treatments are associated with frequent recurrence. Recurrence after treatment might relate to evidence that suggests sexual transmission is integral to the pathogenesis of bacterial vaginosis, which has substantial implications for the development of effective management approaches. STIs disproportionately affect low-income and middle-income countries. We review strategies for case management, focusing on point-of-care tests that hold considerable potential for improving STI control. Lastly, STIs in men who have sex with men have increased since the late 1990s. We discuss the contribution of new biomedical HIV prevention strategies and risk compensation. Overall, this Commission aims to enhance the understanding of some of the key challenges facing the field of STIs, and outlines new approaches to improve the clinical management of STIs and public health.",
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Unemo, M, Bradshaw, CS, Hocking, JS, de Vries, HJC, Francis, SC, Mabey, DC, Marrazzo, JM, Sonder, GJB, Schwebke, JR, Hoornenborg, E, Peeling, RW, Philip, SS, Low, N & Fairley, CK 2017, 'Sexually transmitted infections: Challenges ahead' Lancet Infectious Diseases, vol. 17, no. 8, pp. e235-e279. https://doi.org/10.1016/S1473-3099(17)30310-9

Sexually transmitted infections : Challenges ahead. / Unemo, Magnus; Bradshaw, Catriona S.; Hocking, Jane S.; de Vries, Henry J.C.; Francis, Suzanna C.; Mabey, David C; Marrazzo, Jeanne M.; Sonder, Gerard J.B.; Schwebke, Jane R.; Hoornenborg, Elske; Peeling, Rosanna W.; Philip, Susan S.; Low, Nicola; Fairley, Christopher K.

In: Lancet Infectious Diseases, Vol. 17, No. 8, 08.2017, p. e235-e279.

Research output: Contribution to journalReview ArticleResearchpeer-review

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T1 - Sexually transmitted infections

T2 - Challenges ahead

AU - Unemo, Magnus

AU - Bradshaw, Catriona S.

AU - Hocking, Jane S.

AU - de Vries, Henry J.C.

AU - Francis, Suzanna C.

AU - Mabey, David C

AU - Marrazzo, Jeanne M.

AU - Sonder, Gerard J.B.

AU - Schwebke, Jane R.

AU - Hoornenborg, Elske

AU - Peeling, Rosanna W.

AU - Philip, Susan S.

AU - Low, Nicola

AU - Fairley, Christopher K.

PY - 2017/8

Y1 - 2017/8

N2 - WHO estimated that nearly 1 million people become infected every day with any of four curable sexually transmitted infections (STIs): chlamydia, gonorrhoea, syphilis, and trichomoniasis. Despite their high global incidence, STIs remain a neglected area of research. In this Commission, we have prioritised five areas that represent particular challenges in STI treatment and control. Chlamydia remains the most commonly diagnosed bacterial STI in high-income countries despite widespread testing recommendations, sensitive and specific non-invasive testing techniques, and cheap effective therapy. We discuss the challenges for chlamydia control and evidence to support a shift from the current focus on infection-based screening to improved management of diagnosed cases and of chlamydial morbidity, such as pelvic inflammatory disease. The emergence and spread of antimicrobial resistance in Neisseria gonorrhoeae is globally recognised. We review current and potential future control and treatment strategies, with a focus on novel antimicrobials. Bacterial vaginosis is the most common vaginal disorder in women, but current treatments are associated with frequent recurrence. Recurrence after treatment might relate to evidence that suggests sexual transmission is integral to the pathogenesis of bacterial vaginosis, which has substantial implications for the development of effective management approaches. STIs disproportionately affect low-income and middle-income countries. We review strategies for case management, focusing on point-of-care tests that hold considerable potential for improving STI control. Lastly, STIs in men who have sex with men have increased since the late 1990s. We discuss the contribution of new biomedical HIV prevention strategies and risk compensation. Overall, this Commission aims to enhance the understanding of some of the key challenges facing the field of STIs, and outlines new approaches to improve the clinical management of STIs and public health.

AB - WHO estimated that nearly 1 million people become infected every day with any of four curable sexually transmitted infections (STIs): chlamydia, gonorrhoea, syphilis, and trichomoniasis. Despite their high global incidence, STIs remain a neglected area of research. In this Commission, we have prioritised five areas that represent particular challenges in STI treatment and control. Chlamydia remains the most commonly diagnosed bacterial STI in high-income countries despite widespread testing recommendations, sensitive and specific non-invasive testing techniques, and cheap effective therapy. We discuss the challenges for chlamydia control and evidence to support a shift from the current focus on infection-based screening to improved management of diagnosed cases and of chlamydial morbidity, such as pelvic inflammatory disease. The emergence and spread of antimicrobial resistance in Neisseria gonorrhoeae is globally recognised. We review current and potential future control and treatment strategies, with a focus on novel antimicrobials. Bacterial vaginosis is the most common vaginal disorder in women, but current treatments are associated with frequent recurrence. Recurrence after treatment might relate to evidence that suggests sexual transmission is integral to the pathogenesis of bacterial vaginosis, which has substantial implications for the development of effective management approaches. STIs disproportionately affect low-income and middle-income countries. We review strategies for case management, focusing on point-of-care tests that hold considerable potential for improving STI control. Lastly, STIs in men who have sex with men have increased since the late 1990s. We discuss the contribution of new biomedical HIV prevention strategies and risk compensation. Overall, this Commission aims to enhance the understanding of some of the key challenges facing the field of STIs, and outlines new approaches to improve the clinical management of STIs and public health.

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Unemo M, Bradshaw CS, Hocking JS, de Vries HJC, Francis SC, Mabey DC et al. Sexually transmitted infections: Challenges ahead. Lancet Infectious Diseases. 2017 Aug;17(8):e235-e279. https://doi.org/10.1016/S1473-3099(17)30310-9