TY - JOUR
T1 - Sex-specific prediction of hypothalamic-pituitary-adrenal axis activity by pituitary volume during adolescence: A longitudinal study from 12 to 17 years of age
AU - Kaess, Michael
AU - Simmons, Julian G
AU - Whittle, Sarah
AU - Jovev, Martina
AU - Chanen, Andrew
AU - Yucel, Murat
AU - Pantelis, Christos
AU - Allen, Nicholas Brian
PY - 2013
Y1 - 2013
N2 - To investigate the longitudinal relationship between pituitary gland volume (PGV) and parameters of hypothalamic-pituitary-adrenal axis (HPAA) functioning during adolescence. Methods: Participants were 49 adolescents (19 girls and 30 boys) selected from a larger longitudinal, population-based study of adolescent development. Assessments were conducted at three time points (S1, S2 and S3). MRI sessions were at S1 (age: M= 12.62, SD = 0.45 years) and S3 (M= 16.48, SD = 0.53 years) and multiple assessments of salivary cortisol were undertaken at S2 (M= 15.51, SD = 0.35 years). PGV was measured via previously validated manual tracing methods, and the cortisol awakening response (CAR) and diurnal slope (DSL) were used as indices of HPAA functioning.
AB - To investigate the longitudinal relationship between pituitary gland volume (PGV) and parameters of hypothalamic-pituitary-adrenal axis (HPAA) functioning during adolescence. Methods: Participants were 49 adolescents (19 girls and 30 boys) selected from a larger longitudinal, population-based study of adolescent development. Assessments were conducted at three time points (S1, S2 and S3). MRI sessions were at S1 (age: M= 12.62, SD = 0.45 years) and S3 (M= 16.48, SD = 0.53 years) and multiple assessments of salivary cortisol were undertaken at S2 (M= 15.51, SD = 0.35 years). PGV was measured via previously validated manual tracing methods, and the cortisol awakening response (CAR) and diurnal slope (DSL) were used as indices of HPAA functioning.
UR - http://www.sciencedirect.com/science/article/pii/S030645301300245X
U2 - 10.1016/j.psyneuen.2013.06.028
DO - 10.1016/j.psyneuen.2013.06.028
M3 - Article
SN - 0306-4530
VL - 38
SP - 2694
EP - 2704
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
IS - 11
ER -