Sex-specific expression of a novel gene Tmem184a during mouse testis differentiation

Terje Svingen, Annemiek Beverdam, Pascal Bernard, Peter McClive, Vincent R. Harley, Andrew H. Sinclair, Peter Koopman

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Abstract

During mouse embryogenesis, the fate of the bipotential gonads is sealed around 10.5 days post coitum (dpc) when the Y-linked gene Sry specifies the differentiation of testes in males, whereas in females, absence of Sry results in ovary formation. Apart from the pivotal action of Sry, many other genes are known to be involved in sex determination and subsequent differentiation. Much is still unknown regarding the regulatory hierarchy governing these events and many more sex differentiation genes are yet to be discovered. In this study, we investigated the expression of Tmem 184a, a novel gene encoding a protein of unknown function, but with predicted kinase activity, during mouse embryogenesis. We show that Tmem184a is expressed at high levels in the developing testis from 11.5 dpc, a time of active proliferation and differentiation. Tmem 184a expression is further shown to be expressed exclusively within the Sertoli cells of the developing testis cords, suggesting that it may mediate sex-specific signaling events during Sertoli cell differentiation.

Original languageEnglish
Pages (from-to)983-989
Number of pages7
JournalReproduction
Volume133
Issue number5
DOIs
Publication statusPublished - 1 May 2007
Externally publishedYes

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