Sex-differential non-vaccine-specific immunological effects of diphtheria-tetanus-pertussis and measles vaccination

Fatou Noho-Konteh; Jane U. Adetifa; Momodou Cox; Safayet Hossin; John Reynolds; My Thanh Le; Lady Chilel Sanyang; Abdoulie Drammeh; Magdalena Plebanski; Thorsten Forster; Paul Dickinson; Peter Ghazal; Hilton Whittle; Sarah L. Rowland-Jones; Jayne S. Sutherland; Katie L. Flanagan

doi:10.1093/cid/ciw492

Sex-differential non-vaccine-specific immunological effects of diphtheria-tetanus-pertussis and measles vaccination

Fatou Noho-Konteh, Jane U. Adetifa, Momodou Cox, Safayet Hossin, John Reynolds, My Thanh Le, Lady Chilel Sanyang, Abdoulie Drammeh, Magdalena Plebanski, Thorsten Forster, Paul Dickinson, Peter Ghazal, Hilton Whittle, Sarah L. Rowland-Jones, Jayne S. Sutherland, Katie L. Flanagan

Research output: Contribution to journal › Article › Research › peer-review

38 Citations (Scopus)

Abstract

Vaccines can have nontargeted heterologous effects that manifest as increased protection against nonvaccine infections, as described for measles vaccine (MV), or increased susceptibility to infections and death, as described following diphtheria-tetanus-whole cell pertussis (DTP) vaccination. The mechanisms are unknown, and high-quality immunological studies are lacking. This study was designed to investigate the heterologous effects of MV and DTP in 302 Gambian infants. The results support a sex-differential immunosuppressive effect of DTP on innate proinflammatory responses and T-cell immunity. Males but not females receiving MV had enhanced proinflammatory innate responses. The results point to modified signaling via Toll-like receptor 4 (TLR4) as a possible mechanism for the effects on innate immunity. When both vaccines were administered together, purified protein derivative responses were enhanced in females but downregulated in males. Collectively, these data indicate immunological effects that could account for heterologous effects of MV and DTP, to take forward into prospective trials.

Original language	English
Pages (from-to)	1213-1226
Number of pages	14
Journal	Clinical Infectious Diseases
Volume	63
Issue number	9
DOIs	https://doi.org/10.1093/cid/ciw492
Publication status	Published - 1 Nov 2016

Keywords

heterologous effects
transcriptome
cytokines
innate immunity
T cells

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Noho-Konteh, F., Adetifa, J. U., Cox, M., Hossin, S., Reynolds, J., Le, M. T., Sanyang, L. C., Drammeh, A., Plebanski, M., Forster, T., Dickinson, P., Ghazal, P., Whittle, H., Rowland-Jones, S. L., Sutherland, J. S., & Flanagan, K. L. (2016). Sex-differential non-vaccine-specific immunological effects of diphtheria-tetanus-pertussis and measles vaccination. Clinical Infectious Diseases, 63(9), 1213-1226. https://doi.org/10.1093/cid/ciw492

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title = "Sex-differential non-vaccine-specific immunological effects of diphtheria-tetanus-pertussis and measles vaccination",

abstract = "Vaccines can have nontargeted heterologous effects that manifest as increased protection against nonvaccine infections, as described for measles vaccine (MV), or increased susceptibility to infections and death, as described following diphtheria-tetanus-whole cell pertussis (DTP) vaccination. The mechanisms are unknown, and high-quality immunological studies are lacking. This study was designed to investigate the heterologous effects of MV and DTP in 302 Gambian infants. The results support a sex-differential immunosuppressive effect of DTP on innate proinflammatory responses and T-cell immunity. Males but not females receiving MV had enhanced proinflammatory innate responses. The results point to modified signaling via Toll-like receptor 4 (TLR4) as a possible mechanism for the effects on innate immunity. When both vaccines were administered together, purified protein derivative responses were enhanced in females but downregulated in males. Collectively, these data indicate immunological effects that could account for heterologous effects of MV and DTP, to take forward into prospective trials.",

keywords = "heterologous effects, transcriptome, cytokines, innate immunity, T cells",

author = "Fatou Noho-Konteh and Adetifa, {Jane U.} and Momodou Cox and Safayet Hossin and John Reynolds and Le, {My Thanh} and Sanyang, {Lady Chilel} and Abdoulie Drammeh and Magdalena Plebanski and Thorsten Forster and Paul Dickinson and Peter Ghazal and Hilton Whittle and Rowland-Jones, {Sarah L.} and Sutherland, {Jayne S.} and Flanagan, {Katie L.}",

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Noho-Konteh, F, Adetifa, JU, Cox, M, Hossin, S, Reynolds, J, Le, MT, Sanyang, LC, Drammeh, A, Plebanski, M, Forster, T, Dickinson, P, Ghazal, P, Whittle, H, Rowland-Jones, SL, Sutherland, JS & Flanagan, KL 2016, 'Sex-differential non-vaccine-specific immunological effects of diphtheria-tetanus-pertussis and measles vaccination', Clinical Infectious Diseases, vol. 63, no. 9, pp. 1213-1226. https://doi.org/10.1093/cid/ciw492

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T1 - Sex-differential non-vaccine-specific immunological effects of diphtheria-tetanus-pertussis and measles vaccination

AU - Noho-Konteh, Fatou

AU - Adetifa, Jane U.

AU - Cox, Momodou

AU - Hossin, Safayet

AU - Reynolds, John

AU - Le, My Thanh

AU - Sanyang, Lady Chilel

AU - Drammeh, Abdoulie

AU - Plebanski, Magdalena

AU - Forster, Thorsten

AU - Dickinson, Paul

AU - Ghazal, Peter

AU - Whittle, Hilton

AU - Rowland-Jones, Sarah L.

AU - Sutherland, Jayne S.

AU - Flanagan, Katie L.

N1 - 10.1093/cid/ciw492

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Vaccines can have nontargeted heterologous effects that manifest as increased protection against nonvaccine infections, as described for measles vaccine (MV), or increased susceptibility to infections and death, as described following diphtheria-tetanus-whole cell pertussis (DTP) vaccination. The mechanisms are unknown, and high-quality immunological studies are lacking. This study was designed to investigate the heterologous effects of MV and DTP in 302 Gambian infants. The results support a sex-differential immunosuppressive effect of DTP on innate proinflammatory responses and T-cell immunity. Males but not females receiving MV had enhanced proinflammatory innate responses. The results point to modified signaling via Toll-like receptor 4 (TLR4) as a possible mechanism for the effects on innate immunity. When both vaccines were administered together, purified protein derivative responses were enhanced in females but downregulated in males. Collectively, these data indicate immunological effects that could account for heterologous effects of MV and DTP, to take forward into prospective trials.

AB - Vaccines can have nontargeted heterologous effects that manifest as increased protection against nonvaccine infections, as described for measles vaccine (MV), or increased susceptibility to infections and death, as described following diphtheria-tetanus-whole cell pertussis (DTP) vaccination. The mechanisms are unknown, and high-quality immunological studies are lacking. This study was designed to investigate the heterologous effects of MV and DTP in 302 Gambian infants. The results support a sex-differential immunosuppressive effect of DTP on innate proinflammatory responses and T-cell immunity. Males but not females receiving MV had enhanced proinflammatory innate responses. The results point to modified signaling via Toll-like receptor 4 (TLR4) as a possible mechanism for the effects on innate immunity. When both vaccines were administered together, purified protein derivative responses were enhanced in females but downregulated in males. Collectively, these data indicate immunological effects that could account for heterologous effects of MV and DTP, to take forward into prospective trials.

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KW - transcriptome

KW - cytokines

KW - innate immunity

KW - T cells

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JF - Clinical Infectious Diseases

IS - 9

ER -

Sex-differential non-vaccine-specific immunological effects of diphtheria-tetanus-pertussis and measles vaccination

Abstract

Keywords

UN SDGs

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