Sex-differential heterologous (non-specific) effects of vaccines

an emerging public health issue that needs to be understood and exploited

Research output: Contribution to journalReview ArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Introduction: Vaccines have heterologous effects on the immune system, leading to altered susceptibility to a range of pathogens, and possibly allergy and autoimmunity. Effects are often sex-differential. This review discusses the evidence, mechanisms and public health implications of the non-specific effects of vaccines (NSEs). Areas covered: This article firstly discusses the World Health Organization systematic review of the evidence for sex-differential heterologous effects of vaccines, and further PubMed indexed studies on NSEs on susceptibility to infectious diseases, allergy, autoimmunity and malignancy in animals and humans. Potential immunological mechanisms are evaluated, including sex-differential effects. Finally it describes how advances in systems biology might be applied to study such effects. Expert commentary: This section points out the need to understand immune mechanisms in order to exploit beneficial vaccine effects, and diminish deleterious ones. It suggests analysis of vaccine effects by sex is important, and discusses the future for personalised vaccines that take these effects into account.

Original languageEnglish
Pages (from-to)5-13
Number of pages9
JournalExpert Review of Vaccines
Volume16
Issue number1
DOIs
Publication statusPublished - 2 Jan 2017

Keywords

  • adaptive immunity
  • allergy
  • autoimmunity
  • expanded program on immunisation
  • innate immunity
  • non-targeted effects
  • personalised vaccines
  • Sex
  • systems vaccinology

Cite this

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title = "Sex-differential heterologous (non-specific) effects of vaccines: an emerging public health issue that needs to be understood and exploited",
abstract = "Introduction: Vaccines have heterologous effects on the immune system, leading to altered susceptibility to a range of pathogens, and possibly allergy and autoimmunity. Effects are often sex-differential. This review discusses the evidence, mechanisms and public health implications of the non-specific effects of vaccines (NSEs). Areas covered: This article firstly discusses the World Health Organization systematic review of the evidence for sex-differential heterologous effects of vaccines, and further PubMed indexed studies on NSEs on susceptibility to infectious diseases, allergy, autoimmunity and malignancy in animals and humans. Potential immunological mechanisms are evaluated, including sex-differential effects. Finally it describes how advances in systems biology might be applied to study such effects. Expert commentary: This section points out the need to understand immune mechanisms in order to exploit beneficial vaccine effects, and diminish deleterious ones. It suggests analysis of vaccine effects by sex is important, and discusses the future for personalised vaccines that take these effects into account.",
keywords = "adaptive immunity, allergy, autoimmunity, expanded program on immunisation, innate immunity, non-targeted effects, personalised vaccines, Sex, systems vaccinology",
author = "Flanagan, {Katie L.} and Magdalena Plebanski",
year = "2017",
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doi = "10.1080/14760584.2016.1203260",
language = "English",
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T2 - an emerging public health issue that needs to be understood and exploited

AU - Flanagan, Katie L.

AU - Plebanski, Magdalena

PY - 2017/1/2

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N2 - Introduction: Vaccines have heterologous effects on the immune system, leading to altered susceptibility to a range of pathogens, and possibly allergy and autoimmunity. Effects are often sex-differential. This review discusses the evidence, mechanisms and public health implications of the non-specific effects of vaccines (NSEs). Areas covered: This article firstly discusses the World Health Organization systematic review of the evidence for sex-differential heterologous effects of vaccines, and further PubMed indexed studies on NSEs on susceptibility to infectious diseases, allergy, autoimmunity and malignancy in animals and humans. Potential immunological mechanisms are evaluated, including sex-differential effects. Finally it describes how advances in systems biology might be applied to study such effects. Expert commentary: This section points out the need to understand immune mechanisms in order to exploit beneficial vaccine effects, and diminish deleterious ones. It suggests analysis of vaccine effects by sex is important, and discusses the future for personalised vaccines that take these effects into account.

AB - Introduction: Vaccines have heterologous effects on the immune system, leading to altered susceptibility to a range of pathogens, and possibly allergy and autoimmunity. Effects are often sex-differential. This review discusses the evidence, mechanisms and public health implications of the non-specific effects of vaccines (NSEs). Areas covered: This article firstly discusses the World Health Organization systematic review of the evidence for sex-differential heterologous effects of vaccines, and further PubMed indexed studies on NSEs on susceptibility to infectious diseases, allergy, autoimmunity and malignancy in animals and humans. Potential immunological mechanisms are evaluated, including sex-differential effects. Finally it describes how advances in systems biology might be applied to study such effects. Expert commentary: This section points out the need to understand immune mechanisms in order to exploit beneficial vaccine effects, and diminish deleterious ones. It suggests analysis of vaccine effects by sex is important, and discusses the future for personalised vaccines that take these effects into account.

KW - adaptive immunity

KW - allergy

KW - autoimmunity

KW - expanded program on immunisation

KW - innate immunity

KW - non-targeted effects

KW - personalised vaccines

KW - Sex

KW - systems vaccinology

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JF - Expert Review of Vaccines

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