Sex differences in the renal vascular response to angiotensin II involves the Mas receptor

Tahereh Safari, Medhi Nematbakhsh, Lucinda M Hilliard, Roger G Evans, Katherine M Denton

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29 Citations (Scopus)

Abstract

The renin-angiotensin system (RAS) depressor arm, particularly renal angiotensin type 2 receptor (AT(2) R) and mas receptor (masR) expression, is enhanced in females, which may contribute to renal and cardiovascular protection. We examined the hypotheses that masR activation increases renal blood flow (RBF) at rest and attenuates the reduction in RBF in response to angiotensin II (AngII) infusion in female rats. Furthermore, we postulated that combined activation of the AT(2) R and masR would produce a greater response than masR activation alone. METHODS: In anaesthetised male and female Wistar rats, mean arterial pressure (MAP) and RBF responses during graded AngII infusion (30-1000 ng/kg/min i.v.) were assessed following pre-treatment with vehicle, the masR antagonist A779, or A779 plus the AT(2) R antagonist PD123319. RESULTS: Basal MAP was not altered by any pre-treatment. Basal RBF decreased 20 in female (P
Original languageEnglish
Pages (from-to)150 - 156
Number of pages7
JournalActa Physiologica
Volume206
Issue number2
DOIs
Publication statusPublished - 2012

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