Sex differences in risk factors for aneurysmal subarachnoid haemorrhage

Systematic review and meta-analysis

Sabah Rehman, Berhe W. Sahle, Ronil V. Chandra, Mitchell Dwyer, Amanda G. Thrift, Michele Callisaya, Monique Breslin, Hoang T. Phan, Petr Otahal, Seana Gall

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Background: Aneurysmal subarachnoid haemorrhage (aSAH) disproportionally affects women. We conducted a systematic review and meta-analysis to explore sex differences in aSAH risk factors. Methods: Case-control/cohort studies were searched to November 2017 with sex-specific risk factors for aSAH. Meta-analysis was performed when a risk factor was reported in ≥2 studies. Results: Of 31 studies, 22 were eligible for meta-analysis. Female sex was associated with greater odds of aSAH (HRadjusted 1.90 [1.47–2.46]. There was no detectable difference between the sexes for hypertension (ORadjusted: men 3.13 [2.26–4.34]; women 3.65 [2.87–4.63], p = .18), smoking (ORadjusted: men 2.96 [1.68–5.21]; women 3.11 [1.21–7.97], p = .95), aSAH family history, systolic blood pressure, age and some genetic variations. Alcohol (ORadjusted: men 1.50 [1.04–2.17]; women 0.83 [0.48–1.45], p = .003), high alanine aminotransferase levels, and some gene variants increased the risk of aSAH in men. Reproductive factors, divorce and some genetic variations increased the risk in women. High aspartate aminotransferase levels in men and, diabetes (ORadjusted: men 0.57 [0.32–1.01]; women 0.24 [0.13–0.43], p = .01) and parity in women reduced aSAH risk. Conclusion: We recommend sex-specific re-analysis of existing studies of aSAH risk factors. Known aSAH risk factors (hypertension, smoking and alcohol consumption) should be targeted to prevent aSAH in men and women. Registration PROSPERO (ID: CRD42018091521).

Original languageEnglish
Article number116446
Number of pages9
JournalJournal of the Neurological Sciences
Volume406
DOIs
Publication statusPublished - 15 Nov 2019

Keywords

  • Risk factors
  • Sex characteristics
  • Subarachnoid haemorrhage

Cite this

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title = "Sex differences in risk factors for aneurysmal subarachnoid haemorrhage: Systematic review and meta-analysis",
abstract = "Background: Aneurysmal subarachnoid haemorrhage (aSAH) disproportionally affects women. We conducted a systematic review and meta-analysis to explore sex differences in aSAH risk factors. Methods: Case-control/cohort studies were searched to November 2017 with sex-specific risk factors for aSAH. Meta-analysis was performed when a risk factor was reported in ≥2 studies. Results: Of 31 studies, 22 were eligible for meta-analysis. Female sex was associated with greater odds of aSAH (HRadjusted 1.90 [1.47–2.46]. There was no detectable difference between the sexes for hypertension (ORadjusted: men 3.13 [2.26–4.34]; women 3.65 [2.87–4.63], p = .18), smoking (ORadjusted: men 2.96 [1.68–5.21]; women 3.11 [1.21–7.97], p = .95), aSAH family history, systolic blood pressure, age and some genetic variations. Alcohol (ORadjusted: men 1.50 [1.04–2.17]; women 0.83 [0.48–1.45], p = .003), high alanine aminotransferase levels, and some gene variants increased the risk of aSAH in men. Reproductive factors, divorce and some genetic variations increased the risk in women. High aspartate aminotransferase levels in men and, diabetes (ORadjusted: men 0.57 [0.32–1.01]; women 0.24 [0.13–0.43], p = .01) and parity in women reduced aSAH risk. Conclusion: We recommend sex-specific re-analysis of existing studies of aSAH risk factors. Known aSAH risk factors (hypertension, smoking and alcohol consumption) should be targeted to prevent aSAH in men and women. Registration PROSPERO (ID: CRD42018091521).",
keywords = "Risk factors, Sex characteristics, Subarachnoid haemorrhage",
author = "Sabah Rehman and Sahle, {Berhe W.} and Chandra, {Ronil V.} and Mitchell Dwyer and Thrift, {Amanda G.} and Michele Callisaya and Monique Breslin and Phan, {Hoang T.} and Petr Otahal and Seana Gall",
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language = "English",
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journal = "Journal of the Neurological Sciences",
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Sex differences in risk factors for aneurysmal subarachnoid haemorrhage : Systematic review and meta-analysis. / Rehman, Sabah; Sahle, Berhe W.; Chandra, Ronil V.; Dwyer, Mitchell; Thrift, Amanda G.; Callisaya, Michele; Breslin, Monique; Phan, Hoang T.; Otahal, Petr; Gall, Seana.

In: Journal of the Neurological Sciences, Vol. 406, 116446, 15.11.2019.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Sex differences in risk factors for aneurysmal subarachnoid haemorrhage

T2 - Systematic review and meta-analysis

AU - Rehman, Sabah

AU - Sahle, Berhe W.

AU - Chandra, Ronil V.

AU - Dwyer, Mitchell

AU - Thrift, Amanda G.

AU - Callisaya, Michele

AU - Breslin, Monique

AU - Phan, Hoang T.

AU - Otahal, Petr

AU - Gall, Seana

PY - 2019/11/15

Y1 - 2019/11/15

N2 - Background: Aneurysmal subarachnoid haemorrhage (aSAH) disproportionally affects women. We conducted a systematic review and meta-analysis to explore sex differences in aSAH risk factors. Methods: Case-control/cohort studies were searched to November 2017 with sex-specific risk factors for aSAH. Meta-analysis was performed when a risk factor was reported in ≥2 studies. Results: Of 31 studies, 22 were eligible for meta-analysis. Female sex was associated with greater odds of aSAH (HRadjusted 1.90 [1.47–2.46]. There was no detectable difference between the sexes for hypertension (ORadjusted: men 3.13 [2.26–4.34]; women 3.65 [2.87–4.63], p = .18), smoking (ORadjusted: men 2.96 [1.68–5.21]; women 3.11 [1.21–7.97], p = .95), aSAH family history, systolic blood pressure, age and some genetic variations. Alcohol (ORadjusted: men 1.50 [1.04–2.17]; women 0.83 [0.48–1.45], p = .003), high alanine aminotransferase levels, and some gene variants increased the risk of aSAH in men. Reproductive factors, divorce and some genetic variations increased the risk in women. High aspartate aminotransferase levels in men and, diabetes (ORadjusted: men 0.57 [0.32–1.01]; women 0.24 [0.13–0.43], p = .01) and parity in women reduced aSAH risk. Conclusion: We recommend sex-specific re-analysis of existing studies of aSAH risk factors. Known aSAH risk factors (hypertension, smoking and alcohol consumption) should be targeted to prevent aSAH in men and women. Registration PROSPERO (ID: CRD42018091521).

AB - Background: Aneurysmal subarachnoid haemorrhage (aSAH) disproportionally affects women. We conducted a systematic review and meta-analysis to explore sex differences in aSAH risk factors. Methods: Case-control/cohort studies were searched to November 2017 with sex-specific risk factors for aSAH. Meta-analysis was performed when a risk factor was reported in ≥2 studies. Results: Of 31 studies, 22 were eligible for meta-analysis. Female sex was associated with greater odds of aSAH (HRadjusted 1.90 [1.47–2.46]. There was no detectable difference between the sexes for hypertension (ORadjusted: men 3.13 [2.26–4.34]; women 3.65 [2.87–4.63], p = .18), smoking (ORadjusted: men 2.96 [1.68–5.21]; women 3.11 [1.21–7.97], p = .95), aSAH family history, systolic blood pressure, age and some genetic variations. Alcohol (ORadjusted: men 1.50 [1.04–2.17]; women 0.83 [0.48–1.45], p = .003), high alanine aminotransferase levels, and some gene variants increased the risk of aSAH in men. Reproductive factors, divorce and some genetic variations increased the risk in women. High aspartate aminotransferase levels in men and, diabetes (ORadjusted: men 0.57 [0.32–1.01]; women 0.24 [0.13–0.43], p = .01) and parity in women reduced aSAH risk. Conclusion: We recommend sex-specific re-analysis of existing studies of aSAH risk factors. Known aSAH risk factors (hypertension, smoking and alcohol consumption) should be targeted to prevent aSAH in men and women. Registration PROSPERO (ID: CRD42018091521).

KW - Risk factors

KW - Sex characteristics

KW - Subarachnoid haemorrhage

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U2 - 10.1016/j.jns.2019.116446

DO - 10.1016/j.jns.2019.116446

M3 - Review Article

VL - 406

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

M1 - 116446

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