Sex determination in birds

HINTs from the W sex chromosome?

Research output: Contribution to journalReview ArticleResearchpeer-review

37 Citations (Scopus)

Abstract

Sex in birds is controlled genetically (ZZ male: ZW female), but the genetic mechanism remains unclear. While some evidence points to the involvement of Z sex chromosome dosage, other data favour a dominant female-determining gene carried on the W sex chromosome. An intriguing candidate gene located on the chicken W chromosome is HINTW, which encodes an aberrant form of a hydrolase enzyme. In chicken embryos, HINTW is strongly expressed in the gonads and other tissues of ZW (female) embryos. In vitro biochemical data show that HINTW can interfere with the action of a Z-linked orthologue, HINTZ, which is a bona fide hydrolase enzyme. HINTW is conserved among carinate (flying) birds, and recent molecular analysis indicates that it has undergone positive selection over evolution. However, a differentiated HINTW gene appears to be absent in the flightless ratites. This review examines the evidence for and against a role for HINTW in avian sex determination.

Original languageEnglish
Pages (from-to)279-285
Number of pages7
JournalSexual Development
Volume1
Issue number5
DOIs
Publication statusPublished - 1 Nov 2007
Externally publishedYes

Keywords

  • ASW
  • Chicken sex determination
  • HINTW
  • W sex chromosome
  • WPKCI

Cite this

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title = "Sex determination in birds: HINTs from the W sex chromosome?",
abstract = "Sex in birds is controlled genetically (ZZ male: ZW female), but the genetic mechanism remains unclear. While some evidence points to the involvement of Z sex chromosome dosage, other data favour a dominant female-determining gene carried on the W sex chromosome. An intriguing candidate gene located on the chicken W chromosome is HINTW, which encodes an aberrant form of a hydrolase enzyme. In chicken embryos, HINTW is strongly expressed in the gonads and other tissues of ZW (female) embryos. In vitro biochemical data show that HINTW can interfere with the action of a Z-linked orthologue, HINTZ, which is a bona fide hydrolase enzyme. HINTW is conserved among carinate (flying) birds, and recent molecular analysis indicates that it has undergone positive selection over evolution. However, a differentiated HINTW gene appears to be absent in the flightless ratites. This review examines the evidence for and against a role for HINTW in avian sex determination.",
keywords = "ASW, Chicken sex determination, HINTW, W sex chromosome, WPKCI",
author = "Smith, {C. A.}",
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doi = "10.1159/000108934",
language = "English",
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pages = "279--285",
journal = "Sexual Development",
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}

Sex determination in birds : HINTs from the W sex chromosome? / Smith, C. A.

In: Sexual Development, Vol. 1, No. 5, 01.11.2007, p. 279-285.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Sex determination in birds

T2 - HINTs from the W sex chromosome?

AU - Smith, C. A.

PY - 2007/11/1

Y1 - 2007/11/1

N2 - Sex in birds is controlled genetically (ZZ male: ZW female), but the genetic mechanism remains unclear. While some evidence points to the involvement of Z sex chromosome dosage, other data favour a dominant female-determining gene carried on the W sex chromosome. An intriguing candidate gene located on the chicken W chromosome is HINTW, which encodes an aberrant form of a hydrolase enzyme. In chicken embryos, HINTW is strongly expressed in the gonads and other tissues of ZW (female) embryos. In vitro biochemical data show that HINTW can interfere with the action of a Z-linked orthologue, HINTZ, which is a bona fide hydrolase enzyme. HINTW is conserved among carinate (flying) birds, and recent molecular analysis indicates that it has undergone positive selection over evolution. However, a differentiated HINTW gene appears to be absent in the flightless ratites. This review examines the evidence for and against a role for HINTW in avian sex determination.

AB - Sex in birds is controlled genetically (ZZ male: ZW female), but the genetic mechanism remains unclear. While some evidence points to the involvement of Z sex chromosome dosage, other data favour a dominant female-determining gene carried on the W sex chromosome. An intriguing candidate gene located on the chicken W chromosome is HINTW, which encodes an aberrant form of a hydrolase enzyme. In chicken embryos, HINTW is strongly expressed in the gonads and other tissues of ZW (female) embryos. In vitro biochemical data show that HINTW can interfere with the action of a Z-linked orthologue, HINTZ, which is a bona fide hydrolase enzyme. HINTW is conserved among carinate (flying) birds, and recent molecular analysis indicates that it has undergone positive selection over evolution. However, a differentiated HINTW gene appears to be absent in the flightless ratites. This review examines the evidence for and against a role for HINTW in avian sex determination.

KW - ASW

KW - Chicken sex determination

KW - HINTW

KW - W sex chromosome

KW - WPKCI

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