@article{7c41c59b87524d73b86944027f7bfda6,
title = "Sex- And tissue-specific effects of binge-level prenatal alcohol consumption on DNA methylation at birth",
abstract = "Background: Binge-level prenatal alcohol exposure (PAE) causes developmental abnormalities, which may be mediated in part by epigenetic mechanisms. Despite this, few studies have characterised the association of binge PAE with DNA methylation in offspring. Methods: We investigated the association between binge PAE and genome-wide DNA methylation profiles in a sex-specific manner in neonatal buccal and placental samples. Results: We identified no differentially methylated CpGs or differentially methylated regions (DMRs) at false discovery rate <0.05. However, using a sum-of-ranks approach, we identified a DMR in each tissue of female offspring. The DMR identified in buccal samples is located near regions with previously-reported associations to fetal alcohol spectrum disorder (FASD) and binge PAE. Conclusion: Our findings warrant further replication and highlight a potential epigenetic link between binge PAE and FASD.",
keywords = "binge, buccal, DNA methylation, epigenetics, newborn, placenta, prenatal alcohol exposure",
author = "Loke, {Yuk Jing} and Evelyne Muggli and Richard Saffery and Joanne Ryan and Sharon Lewis and Elliott, {Elizabeth J.} and Jane Halliday and Craig, {Jeffrey M.}",
note = "Funding Information: This work was supported by the Australian National Health and Medical Research Council Grant no. 1011070; Senior Research Fellowship no. 1021252 (J Halliday) and no. 1045161 (R Saffrey), and Practitioner Fellowship no. 1021480 (EJ Elliott); the Medical Research Futures Fund Next Generation Fellowship no. 1135959 (EJ Elliott); and the Victorian State Government{\textquoteright}s Operational Infrastructure Support Program. The study has also received funding from the McCusker Charitable Trust to assist with the biospec-imen collection at birth, Jack Brockhoff Foundation no. 3525 for genome-wide DNA methylation data generation of placenta samples, and Foundation for Children no. 2015-111 for genome-wide DNA methylation data generation of buccal samples. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2021 Future Medicine Ltd.",
year = "2021",
month = dec,
doi = "10.2217/epi-2021-0285",
language = "English",
volume = "13",
pages = "1921--1938",
journal = "Epigenomics",
issn = "1750-1911",
publisher = "Future Medicine Ltd.",
number = "24",
}
