Sex- and age-related differences in autistic behaviours in children with neurofibromatosis type 1

Anita K. Chisholm; Francesca Lami; Kristina M. Haebich; Alex Ure; Amanda Brignell; Tiba Maloof; Natalie A. Pride; Karin S. Walsh; Alice Maier; Melissa Rouel; Yael Granader; Belinda Barton; Hayley Darke; Ian Fuelscher; Gabriel Dabscheck; Vicki A. Anderson; Katrina Williams; Kathryn N. North; Jonathan M. Payne

doi:10.1007/s10803-022-05571-6

Sex- and age-related differences in autistic behaviours in children with neurofibromatosis type 1

Anita K. Chisholm, Francesca Lami, Kristina M. Haebich, Alex Ure, Amanda Brignell, Tiba Maloof, Natalie A. Pride, Karin S. Walsh, Alice Maier, Melissa Rouel, Yael Granader, Belinda Barton, Hayley Darke, Ian Fuelscher, Gabriel Dabscheck, Vicki A. Anderson, Katrina Williams, Kathryn N. North, Jonathan M. Payne

Paediatrics Monash Health

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

This study investigated sex and age differences in autistic behaviours in children with neurofibromatosis type 1 (NF1) who scored within the clinical range on the Social Responsiveness Scale - Second Edition (T score ≥ 60). Thirty-four males and 28 females (3–16 years) were assessed with the Autism Diagnostic Observation Schedule - Second Edition and Autism Diagnostic Interview - Revised. Across both measures, males exhibited greater social communication deficits relative to females. Age-related abatement of social communication difficulties was observed for males but not females. Conversely, no sex differences were found for restricted/repetitive behaviours, which were stable over time for both males and females. The findings are discussed within the context of broader neurodevelopmental considerations that are common in NF1.

Original language	English
Pages (from-to)	2835–2850
Number of pages	16
Journal	Journal of Autism and Developmental Disorders
Volume	53
Issue number	7
DOIs	https://doi.org/10.1007/s10803-022-05571-6
Publication status	Published - Jul 2023

Keywords

Age-related differences
Autism
Autistic
Children
Neurofibromatosis type 1
Sex differences

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10.1007/s10803-022-05571-6

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Chisholm, A. K., Lami, F., Haebich, K. M., Ure, A., Brignell, A., Maloof, T., Pride, N. A., Walsh, K. S., Maier, A., Rouel, M., Granader, Y., Barton, B., Darke, H., Fuelscher, I., Dabscheck, G., Anderson, V. A., Williams, K., North, K. N., & Payne, J. M. (2023). Sex- and age-related differences in autistic behaviours in children with neurofibromatosis type 1. Journal of Autism and Developmental Disorders, 53(7), 2835–2850. https://doi.org/10.1007/s10803-022-05571-6

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title = "Sex- and age-related differences in autistic behaviours in children with neurofibromatosis type 1",

abstract = "This study investigated sex and age differences in autistic behaviours in children with neurofibromatosis type 1 (NF1) who scored within the clinical range on the Social Responsiveness Scale - Second Edition (T score ≥ 60). Thirty-four males and 28 females (3–16 years) were assessed with the Autism Diagnostic Observation Schedule - Second Edition and Autism Diagnostic Interview - Revised. Across both measures, males exhibited greater social communication deficits relative to females. Age-related abatement of social communication difficulties was observed for males but not females. Conversely, no sex differences were found for restricted/repetitive behaviours, which were stable over time for both males and females. The findings are discussed within the context of broader neurodevelopmental considerations that are common in NF1.",

keywords = "Age-related differences, Autism, Autistic, Children, Neurofibromatosis type 1, Sex differences",

author = "Chisholm, {Anita K.} and Francesca Lami and Haebich, {Kristina M.} and Alex Ure and Amanda Brignell and Tiba Maloof and Pride, {Natalie A.} and Walsh, {Karin S.} and Alice Maier and Melissa Rouel and Yael Granader and Belinda Barton and Hayley Darke and Ian Fuelscher and Gabriel Dabscheck and Anderson, {Vicki A.} and Katrina Williams and North, {Kathryn N.} and Payne, {Jonathan M.}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2023",

month = jul,

doi = "10.1007/s10803-022-05571-6",

language = "English",

volume = "53",

pages = "2835–2850",

journal = "Journal of Autism and Developmental Disorders",

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Chisholm, AK, Lami, F, Haebich, KM, Ure, A , Brignell, A, Maloof, T, Pride, NA, Walsh, KS, Maier, A, Rouel, M, Granader, Y, Barton, B, Darke, H, Fuelscher, I, Dabscheck, G, Anderson, VA, Williams, K, North, KN & Payne, JM 2023, 'Sex- and age-related differences in autistic behaviours in children with neurofibromatosis type 1', Journal of Autism and Developmental Disorders, vol. 53, no. 7, pp. 2835–2850. https://doi.org/10.1007/s10803-022-05571-6

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AU - Chisholm, Anita K.

AU - Lami, Francesca

AU - Haebich, Kristina M.

AU - Ure, Alex

AU - Brignell, Amanda

AU - Maloof, Tiba

AU - Pride, Natalie A.

AU - Walsh, Karin S.

AU - Maier, Alice

AU - Rouel, Melissa

AU - Granader, Yael

AU - Barton, Belinda

AU - Darke, Hayley

AU - Fuelscher, Ian

AU - Dabscheck, Gabriel

AU - Anderson, Vicki A.

AU - Williams, Katrina

AU - North, Kathryn N.

AU - Payne, Jonathan M.

PY - 2023/7

Y1 - 2023/7

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AB - This study investigated sex and age differences in autistic behaviours in children with neurofibromatosis type 1 (NF1) who scored within the clinical range on the Social Responsiveness Scale - Second Edition (T score ≥ 60). Thirty-four males and 28 females (3–16 years) were assessed with the Autism Diagnostic Observation Schedule - Second Edition and Autism Diagnostic Interview - Revised. Across both measures, males exhibited greater social communication deficits relative to females. Age-related abatement of social communication difficulties was observed for males but not females. Conversely, no sex differences were found for restricted/repetitive behaviours, which were stable over time for both males and females. The findings are discussed within the context of broader neurodevelopmental considerations that are common in NF1.

KW - Age-related differences

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Sex- and age-related differences in autistic behaviours in children with neurofibromatosis type 1

Abstract

Keywords

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