Seven new loci associated with age-related macular degeneration

Lars G. Fritsche, Wei Chen, Matthew Schu, Brian L. Yaspan, Yi Yu, Gudmar Thorleifsson, Donald Jeffrey Zack, Satoshi Arakawa, Valentina Cipriani, Stephan Ripke, Robert P. Igo, Gabriëlle H.S. Buitendijk, Xueling Sim, Daniel E. Weeks, Robyn H. Guymer, Joanna E Merriam, Peter J. Francis, Gregory Hannum, Anita Agarwal, Ana Maria ArmbrechtIsabelle Audo, Tin Aung, Gaetano R Barile, Mustapha Benchaboune, Alan C. Bird, Paul N. Bishop, Kari E. Branham, Matthew Brooks, Alexander J. Brucker, William H. Cade, Melinda S. Cain, Peter Anthony Campochiaro, Chi Chao Chan, Ching-Yu Cheng, Emily Y. Chew, Kimberly A Chin, Itay Chowers, David G. Clayton, Radu Cojocaru, Yvette P. Conley, Belinda K. Cornes, Mark J Daly, Baljean Dhillon, Albert O. Edwards, Evangelos Evangelou, Jesen A Fagerness, Henry A. Ferreyra, James S. Friedman, Asbjorg Geirsdottir, Ronnie J. George, Christian Gieger, Neel Gupta, Stephanie A Hagstrom, Simon P. Harding, Christos Haritoglou, John R. Heckenlively, Frank G. Holz, Guy Hughes, John P A Ioannidis, Tatsuro Ishibashi, Peronne Joseph, Gyungah Jun, Yoichiro Kamatani, Nicholas Katsanis, Claudia N Keilhauer, Jane C. Khan, Ivana K. Kim, Yutaka Kiyohara, Barbara E K Klein, Ronald Klein, Jaclyn L. Kovach, Igor Kozak, Clara J. Lee, Kristine E. Lee, Peter Lichtner, Andrew J. Lotery, Thomas Meitinger, Paul Mitchell, Saddek Mohand-Saïd, Anthony T. Moore, Denise J. Morgan, Margaux A. Morrison, Chelsea E. Myers, Adam C. Naj, Yusuke Nakamura, Yukinori Okada, Anton Orlin, M. Carolina Ortube, Mohammad I. Othman, Chris Pappas, Kyu Hyung Park, Gayle J.T. Pauer, Neal S. Peachey, Olivier Poch, Rinki Ratna Priya, Robyn Reynolds, Andrea J. Richardson, Raymond Ripp, Guenther Rudolph, Euijung Ryu, José Alain Sahel, Debra A. Schaumberg, Hendrik P.N. Scholl, Stephen G. Schwartz, William K. Scott, Humma Shahid, Haraldur Sigurdsson, Giuliana Silvestri, Theru A. Sivakumaran, R. Theodore Smith, Lucia Sobrin, Eric H Souied, Dwight E. Stambolian, Hreinn Stefansson, Gwen M. Sturgill-Short, Atsushi Takahashi, Nirubol Tosakulwong, Barbara J. Truitt, Evangelia E. Tsironi, André G. Uitterlinden, Cornelia M van Duijn, Lingam Vijaya, Johannes R Vingerling, Eranga N. Vithana, Andrew R. Webster, H. Erich Wichmann, Thomas W. Winkler, Tien Yin Wong, Alan F. Wright, Diana Zelenika, Ming Zhang, Ling Zhao, Kang Zhang, Michael L. Klein, Gregory Scott Hageman, Mark G Lathrop, Kari Stefansson, Rando L Allikmets, Paul N Baird, Michael B. Gorin, Jie Jin Wang, Caroline C.W. Klaver, Johanna M Seddon, Margaret A Pericak-Vance, Sudha K. Iyengar, John R.W. Yates, Anand Swaroop, Bernhard H.F. Weber, Michiaki Kubo, Margaret DeAngelis, Thierry Léveillard, Unnur Thorsteinsdottir, Jonathan L Haines, Lindsay A. Farrer, Iris M. Heid, Gonçalo R. Abecasis

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512 Citations (Scopus)

Abstract

Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborative genome-wide association study, including >17,100 advanced AMD cases and >60,000 controls of European and Asian ancestry. We identified 19 loci associated at P < 5 × 10 -8. These loci show enrichment for genes involved in the regulation of complement activity, lipid metabolism, extracellular matrix remodeling and angiogenesis. Our results include seven loci with associations reaching P < 5 × 10-8 for the first time, near the genes COL8A1-FILIP1L, IER3-DDR1, SLC16A8, TGFBR1, RAD51B, ADAMTS9 and B3GALTL. A genetic risk score combining SNP genotypes from all loci showed similar ability to distinguish cases and controls in all samples examined. Our findings provide new directions for biological, genetic and therapeutic studies of AMD.

Original languageEnglish
Pages (from-to)433-439
Number of pages7
JournalNature Genetics
Volume45
Issue number4
DOIs
Publication statusPublished - Apr 2013
Externally publishedYes

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