TY - JOUR
T1 - Serum vitamin D levels, diabetes and cardio-metabolic risk factors in Aboriginal and Torres Strait Islander Australians
AU - Maple-Brown, Louise J
AU - Hughes, Jaquelyne T
AU - Lu, Zhong Xian
AU - Jeyaraman, Kanakamani
AU - Lawton, Paul D
AU - Jones, Graham Ross Dallas
AU - Ellis, Andrew G
AU - Sinha, Ashim K
AU - Cass, Alan
AU - MacIsaac, Richard J
AU - Jerums, George J
AU - O'Dea, Kerin
PY - 2014
Y1 - 2014
N2 - BACKGROUND: Low levels of serum 25-hydroxy vitamin D (25(OH)D), have been associated with development of type 2 diabetes and cardiovascular disease (CVD); however there are limited data on serum 25(OH)D in Indigenous Australians, a population at high risk for both diabetes and CVD. We aimed to assess levels of serum 25(OH)D in Aboriginal and Torres Strait Islander Australians and to explore relationships between 25(OH)D and cardio-metabolic risk factors and diabetes. METHODS: 592 Aboriginal and/or Torres Strait Islander Australian participants of The eGFR (estimated glomerular filtration rate) Study, a cross-sectional analysis of a cohort study performed in 2007-2011, from urban and remote centres within communities, primary care and tertiary hospitals across Northern Territory, Far North Queensland and Western Australia. Assessment of serum 25(OH)D, cardio-metabolic risk factors (central obesity, diabetes, hypertension, history of cardiovascular disease, current smoker, low HDL-cholesterol), and diabetes (by history or HbA1c >/=6.5 ) was performed. Associations were explored between 25(OH)D and outcome measures of diabetes and number of cardio-metabolic risk factors. RESULTS: The median (IQR) serum 25(OH)D was 60 (45-77) nmol/L, 31 had 25(OH)D /=50 nmol/L, cardio-metabolic risk profile differed for: diabetes (54 , 36 p <0.001), past history of cardiovascular disease (16 , 9 , p = 0.014), waist-hip ratio (0.98, 0.92, p <0.001), urine albumin-creatinine ratio (2.7, 1.5 mg/mmol, p <0.001). The OR (95 CI) for diabetes was 2.02 (1.03 - 3.95) for people in the lowest vs highest tertiles of 25(OH)D (72 nmol/L, respectively) after adjusting for known cardio-metabolic risk factors. CONCLUSION: The percentage of 25(OH)D levels
AB - BACKGROUND: Low levels of serum 25-hydroxy vitamin D (25(OH)D), have been associated with development of type 2 diabetes and cardiovascular disease (CVD); however there are limited data on serum 25(OH)D in Indigenous Australians, a population at high risk for both diabetes and CVD. We aimed to assess levels of serum 25(OH)D in Aboriginal and Torres Strait Islander Australians and to explore relationships between 25(OH)D and cardio-metabolic risk factors and diabetes. METHODS: 592 Aboriginal and/or Torres Strait Islander Australian participants of The eGFR (estimated glomerular filtration rate) Study, a cross-sectional analysis of a cohort study performed in 2007-2011, from urban and remote centres within communities, primary care and tertiary hospitals across Northern Territory, Far North Queensland and Western Australia. Assessment of serum 25(OH)D, cardio-metabolic risk factors (central obesity, diabetes, hypertension, history of cardiovascular disease, current smoker, low HDL-cholesterol), and diabetes (by history or HbA1c >/=6.5 ) was performed. Associations were explored between 25(OH)D and outcome measures of diabetes and number of cardio-metabolic risk factors. RESULTS: The median (IQR) serum 25(OH)D was 60 (45-77) nmol/L, 31 had 25(OH)D /=50 nmol/L, cardio-metabolic risk profile differed for: diabetes (54 , 36 p <0.001), past history of cardiovascular disease (16 , 9 , p = 0.014), waist-hip ratio (0.98, 0.92, p <0.001), urine albumin-creatinine ratio (2.7, 1.5 mg/mmol, p <0.001). The OR (95 CI) for diabetes was 2.02 (1.03 - 3.95) for people in the lowest vs highest tertiles of 25(OH)D (72 nmol/L, respectively) after adjusting for known cardio-metabolic risk factors. CONCLUSION: The percentage of 25(OH)D levels
UR - http://www.dmsjournal.com/content/pdf/1758-5996-6-78.pdf
U2 - 10.1186/1758-5996-6-78
DO - 10.1186/1758-5996-6-78
M3 - Article
VL - 6
SP - 1
EP - 8
JO - Diabetology and Metabolic Syndrome
JF - Diabetology and Metabolic Syndrome
SN - 1758-5996
M1 - 78
ER -
