Serum podocalyxin at 11–13 weeks of gestation in the prediction of small for gestational age neonates

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective: To investigate a potential new marker for the prediction of small for gestational age (SGA) infants. Study design: Nested case-control study involving 280 uncomplicated pregnancies and 70 cases of SGA without pre-eclampsia. Serum podocalyxin was measured at 11–13 weeks of gestation and results were expressed in multiples of the median (MoM). The performance of screening by a combination of maternal history and podocalyxin levels was assessed with ROC curves. Results: SGA was predicted by maternal age, height, South Asian ethnicity, and previous delivery without pre-eclampsia. Median podocalyxin levels were higher in affected than uncomplicated pregnancies (1.303 versus 0.994 MoM, p < 0.001). At a 10% false-positive rate, maternal history identified 40.0% of the cases (AUC = 0.74, 95%CI 0.671–0.809). The addition of podocalyxin increased the detection to 54.3% (AUC = 0.78, 95%CI 0.771–0.842, p = 0.027 for the difference in ROC curves). Conclusion: First-trimester podocalyxin may be useful in screening for SGA infants.

Original languageEnglish
Pages (from-to)784-790
Number of pages7
JournalJournal of Perinatology
Volume39
Issue number6
DOIs
Publication statusPublished - 1 Jun 2019

Cite this

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title = "Serum podocalyxin at 11–13 weeks of gestation in the prediction of small for gestational age neonates",
abstract = "Objective: To investigate a potential new marker for the prediction of small for gestational age (SGA) infants. Study design: Nested case-control study involving 280 uncomplicated pregnancies and 70 cases of SGA without pre-eclampsia. Serum podocalyxin was measured at 11–13 weeks of gestation and results were expressed in multiples of the median (MoM). The performance of screening by a combination of maternal history and podocalyxin levels was assessed with ROC curves. Results: SGA was predicted by maternal age, height, South Asian ethnicity, and previous delivery without pre-eclampsia. Median podocalyxin levels were higher in affected than uncomplicated pregnancies (1.303 versus 0.994 MoM, p < 0.001). At a 10{\%} false-positive rate, maternal history identified 40.0{\%} of the cases (AUC = 0.74, 95{\%}CI 0.671–0.809). The addition of podocalyxin increased the detection to 54.3{\%} (AUC = 0.78, 95{\%}CI 0.771–0.842, p = 0.027 for the difference in ROC curves). Conclusion: First-trimester podocalyxin may be useful in screening for SGA infants.",
author = "Rolnik, {Daniel Lorber} and Yao Wang and Jonathan Hyett and {Silva Costa}, {Fabricio da} and Guiying Nie",
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pages = "784--790",
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Serum podocalyxin at 11–13 weeks of gestation in the prediction of small for gestational age neonates. / Rolnik, Daniel Lorber; Wang, Yao; Hyett, Jonathan; Silva Costa, Fabricio da; Nie, Guiying.

In: Journal of Perinatology, Vol. 39, No. 6, 01.06.2019, p. 784-790.

Research output: Contribution to journalArticleResearchpeer-review

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