Serum lipid and glucose concentrations with a propofol infusion for cardiac surgery

Paul S. Myles, Mark R. Buckland, Denis J. Morgan, Anthony M. Weeks

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11 Citations (Scopus)

Abstract

Objective: To document changes in serum lipids and glucose with a propofol infusion technique for cardiac surgery. Design: Prospective cohort. Setting: University teaching hospital. Participants: 22 elective cardiac surgical patients. Interventions: Frequent venous blood sampling. Measurements and Main Results: Serum lipids and glucose were measured at 10 time periods perioperatively, from preinduction until 4 hours post-cardiopulmonary bypass. Plasma propofol concentrations were also measured in 10 of these patients. There was a significant increase in glucose (P < 0.0005) and decreases in cholesterol (P < 0.0005), high-density lipoprotein (P = 0.004), and low-density lipoprotein (P < 0.0005); there was no significant change in triglycerides (P = 0.39). The propofol infusion resulted in acceptable plasma levels throughout the procedure and allowed early extubation in the intensive care unit, after a mean (SD) of 7.14 (5.9) hours. There was a strong correlation between triglyceride and propofol levels at most time periods (r = 0.38 to 0.98). Conclusions: This study demonstrates that a propofol infusion technique does not result in elevation of serum lipids and supports its increased popularity in maintenance of anesthesia for cardiac surgery.

Original languageEnglish
Pages (from-to)373-378
Number of pages6
JournalJournal of Cardiothoracic and Vascular Anesthesia
Volume9
Issue number4
DOIs
Publication statusPublished - 1995

Keywords

  • anesthesia
  • cardiac surgery
  • lipids
  • propofol

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