TY - JOUR
T1 - Serum inhibin concentrations rise throughout normal male and female puberty
AU - Burger, H. G.
AU - McLachlan, R. I.
AU - Bangah, M.
AU - Quigg, H.
AU - Findlay, J. K.
AU - Robertson, D. M.
AU - De Kretser, D. M.
AU - Warne, G. L.
AU - Werther, G. A.
AU - Hudson, I. L.
AU - Cook, J. J.
AU - Fiedler, R.
AU - Greco, S.
AU - Yong, A. B W
AU - Smith, P.
PY - 1988
Y1 - 1988
N2 - Using a newly developed, sensitive, and specific RIA, we measured the serum concentrations of inhibin, together with those of FSH, LH, and sex steroids, throughout puberty in 99 boys and 102 girls attending a suburban Melbourne school. Serum inhibin levels rose from a geometric mean level of 161 U/L (range, 87-310; 67% confidence interval) at stage I puberty in boys to 442 U/L (range, 300-626) at stage V, while corresponding values in girls were 97 U/L (range, 46-204) and 231 U/L (range, 187-372), respectively. Serum inhibin concentrations were strongly correlated with age and serum FSH, LH, testosterone, and estradiol; all hormones increased in parallel in both boys and girls. After adjustment for age, the partial correlation coefficients remained significant only for testosterone in the boys. We hypothesize that gonadal inhibin production is stimulated by rising gonadotropin levels during pubertal development.
AB - Using a newly developed, sensitive, and specific RIA, we measured the serum concentrations of inhibin, together with those of FSH, LH, and sex steroids, throughout puberty in 99 boys and 102 girls attending a suburban Melbourne school. Serum inhibin levels rose from a geometric mean level of 161 U/L (range, 87-310; 67% confidence interval) at stage I puberty in boys to 442 U/L (range, 300-626) at stage V, while corresponding values in girls were 97 U/L (range, 46-204) and 231 U/L (range, 187-372), respectively. Serum inhibin concentrations were strongly correlated with age and serum FSH, LH, testosterone, and estradiol; all hormones increased in parallel in both boys and girls. After adjustment for age, the partial correlation coefficients remained significant only for testosterone in the boys. We hypothesize that gonadal inhibin production is stimulated by rising gonadotropin levels during pubertal development.
UR - http://www.scopus.com/inward/record.url?scp=0023686593&partnerID=8YFLogxK
M3 - Article
C2 - 3138275
AN - SCOPUS:0023686593
SN - 0021-972X
VL - 67
SP - 689
EP - 694
JO - The Journal of Clinical Endocrinology & Metabolism
JF - The Journal of Clinical Endocrinology & Metabolism
IS - 4
ER -