TY - JOUR
T1 - Serum inhibin A and B concentrations during the menstrual cycle in mothers of spontaneous dizygotic twins
AU - Gilfillan, Christopher P.
AU - Montgomery, Grant W.
AU - Zhu, Gu
AU - Martin, Nicholas G.
AU - Groone, N. P.
AU - Robertson, David M.
PY - 2003/2/1
Y1 - 2003/2/1
N2 - Dizygotic twinning in humans is influenced by genetic factors suggesting inherited variation affects follicle development and predisposes to double ovulations. In a previous study, we conducted a detailed examination of follicle development and variation in hormone concentrations during the menstrual cycle in mothers of DZ twins (MODZT) compared with an age-matched control group of mothers of singletons. We did not detect differences in FSH concentrations between mothers of twins and mothers of singletons. Serum inhibin concentrations were measured by a radioimmunoassay that did not distinguish between dimeric inhibin A and B forms and free inhibin α subunit. We therefore analyzed the samples from this study with specific assays to determine whether concentrations of inhibin A and B were different between MODZT and controls and therefore contribute to the twinning phenotype. There were no significant differences between MODZT with single ovulations and control women in inhibin A and B concentrations during the cycle, including the critical period for the selection of the dominant follicle. These data suggest that the genetic cause of twinning is not associated with changes in FSH concentrations or recognised feedback mechanisms regulating FSH release.
AB - Dizygotic twinning in humans is influenced by genetic factors suggesting inherited variation affects follicle development and predisposes to double ovulations. In a previous study, we conducted a detailed examination of follicle development and variation in hormone concentrations during the menstrual cycle in mothers of DZ twins (MODZT) compared with an age-matched control group of mothers of singletons. We did not detect differences in FSH concentrations between mothers of twins and mothers of singletons. Serum inhibin concentrations were measured by a radioimmunoassay that did not distinguish between dimeric inhibin A and B forms and free inhibin α subunit. We therefore analyzed the samples from this study with specific assays to determine whether concentrations of inhibin A and B were different between MODZT and controls and therefore contribute to the twinning phenotype. There were no significant differences between MODZT with single ovulations and control women in inhibin A and B concentrations during the cycle, including the critical period for the selection of the dominant follicle. These data suggest that the genetic cause of twinning is not associated with changes in FSH concentrations or recognised feedback mechanisms regulating FSH release.
UR - http://www.scopus.com/inward/record.url?scp=0037321568&partnerID=8YFLogxK
U2 - 10.1375/136905203762687870
DO - 10.1375/136905203762687870
M3 - Article
C2 - 12626226
AN - SCOPUS:0037321568
VL - 6
SP - 27
EP - 33
JO - Twin Research and Human Genetics
JF - Twin Research and Human Genetics
SN - 1832-4274
IS - 1
ER -