TY - JOUR
T1 - Serum, fecal, and breast milk rotavirus antibodies as indices of infection in mother-infant pairs
AU - Bishop, Ruth F
AU - Bugg, H C
AU - Masendycz, Paul J
AU - Lund, J S
AU - Gorrell, Rebecca Jane
AU - Barnes, Graeme
PY - 1996
Y1 - 1996
N2 - Sixty-eight mother-infant pairs were followed for 12-17 months after birth. Rotavirus infections in children were detected by EIA of weekly fecal antigen and anti-rotavirus IgA levels, by EIA of anti-rotavirus IgG in sera at birth, 6, or 12-17 months of age, and by anti-rotavirus EIA IgA and neutralizing antibody (NA) in monthly samples of maternal breast milk. Primary rotavirus infection was detected in 26 children (in 15 [58 by fecal excretion, 12 [46 by IgG seroconversion, and 22 [85 by elevations of IgA anti-rotavirus antibodies [IgA coproconversion] in consecutive fecal specimens). Rotavirus challenge was detected by rises in levels of NA in breast milk in 9 (47 ) of 19 mothers, including 5 (26 ) from pairs in which there was no other evidence of rotavirus infection. Reinfections were detected in 2 children by rotavirus excretion and in 4 by coproconversion. IgA coproconversion is the most sensitive technique for detection of symptomatic and asymptomatic rotavirus infection in young children.
AB - Sixty-eight mother-infant pairs were followed for 12-17 months after birth. Rotavirus infections in children were detected by EIA of weekly fecal antigen and anti-rotavirus IgA levels, by EIA of anti-rotavirus IgG in sera at birth, 6, or 12-17 months of age, and by anti-rotavirus EIA IgA and neutralizing antibody (NA) in monthly samples of maternal breast milk. Primary rotavirus infection was detected in 26 children (in 15 [58 by fecal excretion, 12 [46 by IgG seroconversion, and 22 [85 by elevations of IgA anti-rotavirus antibodies [IgA coproconversion] in consecutive fecal specimens). Rotavirus challenge was detected by rises in levels of NA in breast milk in 9 (47 ) of 19 mothers, including 5 (26 ) from pairs in which there was no other evidence of rotavirus infection. Reinfections were detected in 2 children by rotavirus excretion and in 4 by coproconversion. IgA coproconversion is the most sensitive technique for detection of symptomatic and asymptomatic rotavirus infection in young children.
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8752287
M3 - Article
VL - 174
SP - S22 - S29
JO - The Journal of Infectious Diseases
JF - The Journal of Infectious Diseases
SN - 0022-1899
IS - Suppl 1
ER -