Serum antioxidant vitamins and malondialdehyde levels in patients with obsessive-compulsive disorder

Mohammad Hasanuzzaman Shohag, Mohammad Ashik Ullah, Mohammad A. Azad, Mohammad S. Islam, Shalahuddin Qusar, Shelina F. Shahid, Abul Hasnat

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12 Citations (Scopus)

Abstract

Objectives: Free radicals have been implicated in the pathophysiology of some psychiatric disorders. To examine the role of free radicals in the etiopathogenesis of obsessive-compulsive disorder (OCD), we aimed to assess whether the antioxidant vitamins (E, C and A) activity and malondialdehyde (MDA) levels were associated with OCD. Methods: 48 OCD patients diagnosed according to DSM-IV and 48 healthy volunteers as control group were included in this study. Serum levels of vitamin E and A were determined using RP-HPLC, whereas vitamin C was estimated by phenyl-hydrazine spectrophotometric method. MDA level was measured using UV-VIS spectroscopy. Results: Significant differences in serum vitamin E and C levels were observed between the OCD and control groups (p<0.05). MDA levels were found significantly higher in OCD subjects (p<0.05). Conclusion: Our study found an overall imbalance in antioxidant vitamins level in OCD patients, which may have potential role in etiopathogenesis of the disease process.

Original languageEnglish
Pages (from-to)10-14
Number of pages5
JournalGerman Journal of Psychiatry
Volume15
Issue number1
Publication statusPublished - 1 May 2012
Externally publishedYes

Keywords

  • Antioxidants
  • Malondialdehyde
  • OCD
  • Vitamins

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