TY - JOUR
T1 - Serum 25-hydroxyvitamin D deficiency and the 5-year incidence of CKD
AU - Damasiewicz, Matthew J
AU - Magliano, Dianna J
AU - Daly, Robin M
AU - Gagnon, Claudia
AU - Lu, Zhong X
AU - Sikaris, Ken A
AU - Ebeling, Peter R
AU - Chadban, Steven J
AU - Atkins, Robert C
AU - Kerr, Peter G
AU - Shaw, Jonathan E
AU - Polkinghorne, Kevan R
PY - 2013
Y1 - 2013
N2 - Low serum 25-hydroxyvitamin D (25[OH]D) levels have been associated with chronic kidney disease in cross-sectional studies. However, this association has not been studied prospectively in a large general population-based cohort. STUDY DESIGN: Prospective cohort study. SETTING PARTICIPANTS: 6,180 adults 25 years or older participating in the baseline and 5-year follow-up phases of the Australian Diabetes, Obesity and Lifestyle (AusDiab) Study. PREDICTOR: Serum 25(OH)D levels /=2.5 mg/mmol [>/=22.1 mg/g] for men and >/=3.5 mg/mmol [>/=30.9 mg/g] for women). RESULTS: 623 (10.9 ) participants were vitamin D deficient, 161 developed incident reduced eGFR, and 222 developed incident albuminuria. In participants with and without vitamin D deficiency, annual age-standardized incidences were 0.92 (95 CI, 0.56 -1.30 ) and 0.59 (95 CI, 0.51 -0.68 ), respectively, for eGFR
AB - Low serum 25-hydroxyvitamin D (25[OH]D) levels have been associated with chronic kidney disease in cross-sectional studies. However, this association has not been studied prospectively in a large general population-based cohort. STUDY DESIGN: Prospective cohort study. SETTING PARTICIPANTS: 6,180 adults 25 years or older participating in the baseline and 5-year follow-up phases of the Australian Diabetes, Obesity and Lifestyle (AusDiab) Study. PREDICTOR: Serum 25(OH)D levels /=2.5 mg/mmol [>/=22.1 mg/g] for men and >/=3.5 mg/mmol [>/=30.9 mg/g] for women). RESULTS: 623 (10.9 ) participants were vitamin D deficient, 161 developed incident reduced eGFR, and 222 developed incident albuminuria. In participants with and without vitamin D deficiency, annual age-standardized incidences were 0.92 (95 CI, 0.56 -1.30 ) and 0.59 (95 CI, 0.51 -0.68 ), respectively, for eGFR
UR - http://www.sciencedirect.com/science/article/pii/S0272638613006665
UR - https://www.scopus.com/pages/publications/84879422068
U2 - 10.1053/j.ajkd.2013.03.010
DO - 10.1053/j.ajkd.2013.03.010
M3 - Article
SN - 0272-6386
VL - 62
SP - 58
EP - 66
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 1
ER -
