Serum 25-hydroxyvitamin D deficiency and the 5-year incidence of CKD

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Abstract

Low serum 25-hydroxyvitamin D (25[OH]D) levels have been associated with chronic kidney disease in cross-sectional studies. However, this association has not been studied prospectively in a large general population-based cohort. STUDY DESIGN: Prospective cohort study. SETTING PARTICIPANTS: 6,180 adults 25 years or older participating in the baseline and 5-year follow-up phases of the Australian Diabetes, Obesity and Lifestyle (AusDiab) Study. PREDICTOR: Serum 25(OH)D levels /=2.5 mg/mmol [>/=22.1 mg/g] for men and >/=3.5 mg/mmol [>/=30.9 mg/g] for women). RESULTS: 623 (10.9 ) participants were vitamin D deficient, 161 developed incident reduced eGFR, and 222 developed incident albuminuria. In participants with and without vitamin D deficiency, annual age-standardized incidences were 0.92 (95 CI, 0.56 -1.30 ) and 0.59 (95 CI, 0.51 -0.68 ), respectively, for eGFR
Original languageEnglish
Pages (from-to)58-66
Number of pages9
JournalAmerican Journal of Kidney Diseases
Volume62
Issue number1
DOIs
Publication statusPublished - 2013

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