Seroprevalence of nipah virus infection in peninsular Malaysia

Ming Yen Yong, Soo Ching Lee, Romano Ngui, Yvonne Ai Lian Lim, Maude E. Phipps, Li Yen Chang

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    Abstract

    Nipah virus (NiV) outbreak occurred in Malaysia in 1998. The natural host reservoir for NiV is Pteropus bats, which are commonly found throughout Malaysia. Humans become infected when NiV spills over from the reservoir species. In this study, NiV serosurveillance in Peninsular Malaysia, particularly among the indigenous population, was performed. The collected samples were tested for presence of NiV antibodies using a comparative indirect enzyme-linked immunosorbent assay based on the recombinant NiV nucleocapsid (rNiV-N) protein. We found that 10.73% of the participants recruited in this study had antibodies against rNiV-N, suggesting possible exposure to NiV.

    Original languageEnglish
    Pages (from-to)S370-S374
    Number of pages5
    JournalThe Journal of infectious diseases
    Volume221
    Issue numberSuppl 4
    DOIs
    Publication statusPublished - 1 May 2020

    Keywords

    • Comparative indirect ELISA
    • Indigenous population
    • Malaysia
    • Nipah virus
    • Nucleocapsid protein
    • Serosurveillance

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