TY - JOUR
T1 - Serial MRI in multiple sclerosis
T2 - A prospective pilot study of lesion load, whole brain volume and thalamic atrophy
AU - Taylor, I.
AU - Butzkueven, H.
AU - Litewka, L.
AU - MacGregor, L. R.
AU - Szoeke, C.
AU - Cook, M.
AU - Mitchell, P.
AU - Kilpatrick, T. J.
AU - Tubridy, Niall
PY - 2004/1/1
Y1 - 2004/1/1
N2 - Using serial magnetic resonance imaging (MRI), we investigated the relationship between diffuse cerebral atrophy, T1 and T2 lesion volumes, mean thalamic volumes and clinical progression in patients with established multiple sclerosis (MS). Eleven patients were included in this prospective serial study. Cerebral volumes, T1 hypointense lesion volumes, and T2 hyperintense lesion volumes at baseline and at up to 3 years follow-up were assessed on MRI brain scans. As a putative measure of cerebral atrophy mean thalamic volumes were also obtained. The outcome measures were the MRI parameters and disability on Kurtzke's expanded disability status scale (EDSS). Of the 11 patients 6 worsened clinically as measured by an increase of 0.5 or more on the EDSS. Cerebral atrophy occurred in 91% of patients and was independent of changes in lesion volumes and was not associated with disease progression as determined by the EDSS.
AB - Using serial magnetic resonance imaging (MRI), we investigated the relationship between diffuse cerebral atrophy, T1 and T2 lesion volumes, mean thalamic volumes and clinical progression in patients with established multiple sclerosis (MS). Eleven patients were included in this prospective serial study. Cerebral volumes, T1 hypointense lesion volumes, and T2 hyperintense lesion volumes at baseline and at up to 3 years follow-up were assessed on MRI brain scans. As a putative measure of cerebral atrophy mean thalamic volumes were also obtained. The outcome measures were the MRI parameters and disability on Kurtzke's expanded disability status scale (EDSS). Of the 11 patients 6 worsened clinically as measured by an increase of 0.5 or more on the EDSS. Cerebral atrophy occurred in 91% of patients and was independent of changes in lesion volumes and was not associated with disease progression as determined by the EDSS.
KW - Atrophy
KW - Magnetic resonance imaging
KW - Multiple sclerosis
KW - Thalamic volume
UR - http://www.scopus.com/inward/record.url?scp=1342346730&partnerID=8YFLogxK
U2 - 10.1016/S0967-5868(03)00145-0
DO - 10.1016/S0967-5868(03)00145-0
M3 - Article
C2 - 14732374
AN - SCOPUS:1342346730
VL - 11
SP - 153
EP - 158
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
SN - 0967-5868
IS - 2
ER -