Synthetic polymer chemists have always sought to approach the precision over monomer sequence exemplified by natural biopolymers (e.g. DNA and proteins). The ability to translate this molecular precision to sequence-controlled synthetic analogues would allow polymer chemists to not only mimic but also potentially enhance the properties of biomacromolecules paving the way for many applications in a wide range of fields including materials science and nanomedicine. Solid-phase peptide synthesis enabled the preparation of sequence-defined oligomers although this approach can be time-consuming, costly (due to many protection/deprotection steps), challenging to scale up and limited to the synthesis of low molecular weight materials.
- Controlled radical polymerization
- Sequence control