Sequence-controlled polymers via controlled radical polymerization

Richard Whitfield, Nghia P. Truong, Athina Anastasaki

Research output: Contribution to journalComment / DebateOtherpeer-review

Abstract

Synthetic polymer chemists have always sought to approach the precision over monomer sequence exemplified by natural biopolymers (e.g. DNA and proteins). The ability to translate this molecular precision to sequence-controlled synthetic analogues would allow polymer chemists to not only mimic but also potentially enhance the properties of biomacromolecules paving the way for many applications in a wide range of fields including materials science and nanomedicine. Solid-phase peptide synthesis enabled the preparation of sequence-defined oligomers although this approach can be time-consuming, costly (due to many protection/deprotection steps), challenging to scale up and limited to the synthesis of low molecular weight materials.
Original languageEnglish
Number of pages1
JournalChimia
Volume73
Issue number4
DOIs
Publication statusPublished - 1 Jan 2019
Externally publishedYes

Keywords

  • Controlled radical polymerization
  • Multiblocks
  • Sequence control

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