Sequence-controlled multi-block glycopolymers via Cu(0) mediated living radical polymerization

Qiang Zhang, Jennifer Collins, Athina Anastasaki, Russell Wallis, Daniel A Mitchell, C Remzi Becer, Paul Wilson, David M. Haddleton

Research output: Chapter in Book/Report/Conference proceedingConference PaperOtherpeer-review

2 Citations (Scopus)


Synthetic glycopolymers with pendant saccharides bind to mammalian carbohydrate-recognition proteins with high affinity due to their multivalency and primary structure. However, glycoproteins function in nature via an exquisitely tuned "glycocode" and mimicking this code remains an interesting challenge in polymer chemistry. In order to address this we have synthesized glycomonomers via a [3+2] cycloaddition reaction between sugar-alkyne and azido-acrylates and these monomers were used to synthesize a series of sequence controlled glycopolymers (SCGP) using single electron transfer living radical polymerization (SET-LRP).

Original languageEnglish
Title of host publicationSequence-Controlled Polymers
Subtitle of host publicationSynthesis, Self-Assembly, and Properties
EditorsJean-Franço̧is Lutz, Tara Y Meyer, Makoto Ouchi, Mitsuo Sawamoto
Place of PublicationWashington DC USA
PublisherAmerican Chemical Society
Number of pages22
ISBN (Electronic)9780841230019
Publication statusPublished - 2014
Externally publishedYes

Publication series

NameACS Symposium Series
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

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