Sequence-controlled multi-block glycopolymers to inhibit DC-SIGN-gp120 binding

Qiang Zhang; Jennifer Collins; Athina Anastasaki; Russell Wallis; Daniel A. Mitchell; C. Remzi Becer; David M. Haddleton

doi:10.1002/anie.201300068

Sequence-controlled multi-block glycopolymers to inhibit DC-SIGN-gp120 binding

Qiang Zhang, Jennifer Collins, Athina Anastasaki, Russell Wallis, Daniel A. Mitchell, C. Remzi Becer, David M. Haddleton

Research output: Contribution to journal › Article › Research › peer-review

170 Citations (Scopus)

Abstract

Chain of command: Multi-block glycopolymers made of mannose (M, see figure), glucose, and di(ethylene glycol) ethyl ether (D) monomers were synthesized using a technique to control the polymer sequence. These highly monodisperse glycopolymers were then tested for binding and inhibition of DC-SIGN, a protein important for HIV infection.

Original language	English
Pages (from-to)	4435-4439
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	16
DOIs	https://doi.org/10.1002/anie.201300068
Publication status	Published - 15 Apr 2013
Externally published	Yes

Keywords

block copolymers
glycosylation
polymerization
polymers
supramolecular chemistry

Access to Document

10.1002/anie.201300068

Link to publication in Scopus

Cite this

@article{510c400b019c4a1497f9bb049266a2b0,

title = "Sequence-controlled multi-block glycopolymers to inhibit DC-SIGN-gp120 binding",

abstract = "Chain of command: Multi-block glycopolymers made of mannose (M, see figure), glucose, and di(ethylene glycol) ethyl ether (D) monomers were synthesized using a technique to control the polymer sequence. These highly monodisperse glycopolymers were then tested for binding and inhibition of DC-SIGN, a protein important for HIV infection.",

keywords = "block copolymers, glycosylation, polymerization, polymers, supramolecular chemistry",

author = "Qiang Zhang and Jennifer Collins and Athina Anastasaki and Russell Wallis and Mitchell, {Daniel A.} and Becer, {C. Remzi} and Haddleton, {David M.}",

year = "2013",

month = apr,

day = "15",

doi = "10.1002/anie.201300068",

language = "English",

volume = "52",

pages = "4435--4439",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "Wiley-Blackwell",

number = "16",

}

Sequence-controlled multi-block glycopolymers to inhibit DC-SIGN-gp120 binding. / Zhang, Qiang; Collins, Jennifer; Anastasaki, Athina; Wallis, Russell; Mitchell, Daniel A.; Becer, C. Remzi; Haddleton, David M.

In: Angewandte Chemie - International Edition, Vol. 52, No. 16, 15.04.2013, p. 4435-4439.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Sequence-controlled multi-block glycopolymers to inhibit DC-SIGN-gp120 binding

AU - Zhang, Qiang

AU - Collins, Jennifer

AU - Anastasaki, Athina

AU - Wallis, Russell

AU - Mitchell, Daniel A.

AU - Becer, C. Remzi

AU - Haddleton, David M.

PY - 2013/4/15

Y1 - 2013/4/15

N2 - Chain of command: Multi-block glycopolymers made of mannose (M, see figure), glucose, and di(ethylene glycol) ethyl ether (D) monomers were synthesized using a technique to control the polymer sequence. These highly monodisperse glycopolymers were then tested for binding and inhibition of DC-SIGN, a protein important for HIV infection.

AB - Chain of command: Multi-block glycopolymers made of mannose (M, see figure), glucose, and di(ethylene glycol) ethyl ether (D) monomers were synthesized using a technique to control the polymer sequence. These highly monodisperse glycopolymers were then tested for binding and inhibition of DC-SIGN, a protein important for HIV infection.

KW - block copolymers

KW - glycosylation

KW - polymerization

KW - polymers

KW - supramolecular chemistry

UR - http://www.scopus.com/inward/record.url?scp=84876229405&partnerID=8YFLogxK

U2 - 10.1002/anie.201300068

DO - 10.1002/anie.201300068

M3 - Article

C2 - 23494988

AN - SCOPUS:84876229405

VL - 52

SP - 4435

EP - 4439

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 16

ER -