Sequence-controlled multi-block glycopolymers to inhibit DC-SIGN-gp120 binding

Qiang Zhang, Jennifer Collins, Athina Anastasaki, Russell Wallis, Daniel A. Mitchell, C. Remzi Becer, David M. Haddleton

Research output: Contribution to journalArticleResearchpeer-review

170 Citations (Scopus)

Abstract

Chain of command: Multi-block glycopolymers made of mannose (M, see figure), glucose, and di(ethylene glycol) ethyl ether (D) monomers were synthesized using a technique to control the polymer sequence. These highly monodisperse glycopolymers were then tested for binding and inhibition of DC-SIGN, a protein important for HIV infection.

Original languageEnglish
Pages (from-to)4435-4439
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number16
DOIs
Publication statusPublished - 15 Apr 2013
Externally publishedYes

Keywords

  • block copolymers
  • glycosylation
  • polymerization
  • polymers
  • supramolecular chemistry

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