Sequence and expression of mouse γ-renin

C. C. Drinkwater, B. A. Evans, R. I. Richards

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Abstract

Mouse γ-renin is a member of the group of serine proteases known as glandular kallikreins. These highly homologous proteins process a diverse range of growth factors and hormones to their biologically active form, usually by cleavage at a basic residue. γ-Renin, however, cleaves at a Leu-Leu bond in a similar fashion to renin. We have identified and sequenced the gene and a cDNA encoding γ-renin. The complete predicted amino acid sequence was determined, and residues that may be important in the unusual cleavage pattern exhibited by γ-renin are discussed. The nucleotide sequence enabled design of a gene-specific oligodeoxyribonucleotide which was used to determine in which mouse tissues γ-renin is expressed.

Original languageEnglish
Pages (from-to)8565-8568
Number of pages4
JournalJournal of Biological Chemistry
Volume263
Issue number18
Publication statusPublished - 1 Jan 1988
Externally publishedYes

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