Sequence-addressable DNA logic

Nicolas H. Voelcker, Kevin M. Guckian, Alan Saghatelian, M. Reza Ghadiri

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)


A study was conducted to present a series of DNA-based logic gates that operated with compatible oligonucleotide inputs and outputs. A DNA-based half-adder was assembled through the combination of a AND logic gate and and XOR gate in a shared solution demonstrating both the sequence assessability and cross-compatibility of the gates. It was found that the use of a single molecular-recognition platform gave these gates the potential, to be assembled into higher-order circuits that were wired through through the information contained within oligonucleotide sequences. Two XOR gates were wired into an OR gate and verified basic communication between these gates, to demonstrate the potential. It was found that input oligonucleotides first bound single-stranded regions and proceeded, to replace the base pairing in the smaller duplex through a three-way branch migration mechanism.

Original languageEnglish
Pages (from-to)427-431
Number of pages5
Issue number4
Publication statusPublished - 1 Apr 2008
Externally publishedYes


  • DNA
  • Logic gates
  • Molecular electronics
  • Molecular recognition
  • Oligonucleotides

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