Septic shock: Desperately seeking treatment

Olivier Huet, Jaye P. F. Chin-Dusting

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Abstract

Septic shock results from the dysregulation of the innate immune response following infection. Despite major advances in fundamental and clinical research, patients diagnosed with septic shock still have a poor prognostic outcome, with a mortality rate of up to 50%. Indeed, the reasons leading to septic shock are still poorly understood. First postulated 30 years ago, the general view of septic shock as an acute and overwhelming inflammatory response still prevails today. Recently, the fact thatnumerous clinical trials have failed to demonstrate any positive medical outcomes has caused us to question our fundamental understanding of this condition. New and sophisticated technologies now allow us to accurately profile the various stages and contributory components of the inflammatory response defining septic shock, and many studies now report a more complex inflammatory response, particularlyduring the early phase of sepsis. In addition, novel experimental approaches, using more clinically relevant animal models, to standardize and stratify research outcomes are now being argued for. In thepresent review, we discuss the most recent findings in relation to our understanding of the underlying mechanisms involved in septic shock, and highlight the attempts made to improve animal experimenta models. We also review recent studies reporting promising results with two vastly different therapeutic approaches influencing the renin-angiotensin system and applying mesenchymal stem cells for clinical intervention.

Original languageEnglish
Pages (from-to)31-39
Number of pages9
JournalClinical Science
Volume126
Issue number1
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Inflammation
  • Mesenchymal stem cell
  • Renin-Angiotensin system
  • Septic shock

Cite this