Sepsis-induced acute kidney injury

Johannes Karl Martensson, Rinaldo Bellomo

Research output: Contribution to journalLetterOther

Abstract

Acute kidney injury (AKI) is a serious yet potentially reversible complication of sepsis. Several molecular mechanisms involved in the development of septic AKI have been identified. These mechanisms may be important targets in the development of future therapies. This review highlights the role of the innate immune response to sepsis and its downstream effects on kidney structure and function with special reference to the adaptive cellular response and glomerular hemodynamic changes. In addition, current evidence surrounding the management of patients with septic AKI is summarized. Finally, potential novel therapies for septic AKI are presented.
Original languageEnglish
Pages (from-to)649 - 660
Number of pages12
JournalCritical Care Clinics
Volume31
Issue number4
DOIs
Publication statusPublished - 2015

Cite this

Martensson, Johannes Karl ; Bellomo, Rinaldo. / Sepsis-induced acute kidney injury. In: Critical Care Clinics. 2015 ; Vol. 31, No. 4. pp. 649 - 660.
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Sepsis-induced acute kidney injury. / Martensson, Johannes Karl; Bellomo, Rinaldo.

In: Critical Care Clinics, Vol. 31, No. 4, 2015, p. 649 - 660.

Research output: Contribution to journalLetterOther

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AU - Martensson, Johannes Karl

AU - Bellomo, Rinaldo

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N2 - Acute kidney injury (AKI) is a serious yet potentially reversible complication of sepsis. Several molecular mechanisms involved in the development of septic AKI have been identified. These mechanisms may be important targets in the development of future therapies. This review highlights the role of the innate immune response to sepsis and its downstream effects on kidney structure and function with special reference to the adaptive cellular response and glomerular hemodynamic changes. In addition, current evidence surrounding the management of patients with septic AKI is summarized. Finally, potential novel therapies for septic AKI are presented.

AB - Acute kidney injury (AKI) is a serious yet potentially reversible complication of sepsis. Several molecular mechanisms involved in the development of septic AKI have been identified. These mechanisms may be important targets in the development of future therapies. This review highlights the role of the innate immune response to sepsis and its downstream effects on kidney structure and function with special reference to the adaptive cellular response and glomerular hemodynamic changes. In addition, current evidence surrounding the management of patients with septic AKI is summarized. Finally, potential novel therapies for septic AKI are presented.

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JO - Critical Care Clinics

JF - Critical Care Clinics

SN - 0749-0704

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