Separate roles for β2- and β3-adrenoceptors in memory consolidation

M. E. Gibbs, R. J. Summers

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Consolidation of a labile memory which would not normally be stored can be achieved by intracerebral administration of noradrenaline. In a series of experiments using discriminated, one trial passive avoidance learning with the day-old chick, the effect of noradrenaline has been shown to be due to actions at different subtypes of adrenoceptors. The effect of noradrenaline is dose-dependent, with a moderate dose producing memory consolidation. However, higher doses of noradrenaline (0.3-10 nmol/hemisphere) prevent consolidation, an effect not seen with isoprenaline suggesting that these doses stimulate α-adrenoceptors. The promotion of memory consolidation by noradrenaline or isoprenaline at low doses was attributable to β3- adrenoceptors and at medium doses to β2-adrenoceptors. At higher doses of noradrenaline, there was α1-adrenoceptor-mediated inhibition of memory consolidation. Consolidation can also be achieved by administration of either β2- or β3-adrenoceptor agonists at specific times after training. Although these two adrenoceptors both promoted memory consolidation, there was a differential action on the stages of memory formation. The dose- response curve to the β3- and the β2-agonists was shifted by the appropriate antagonist but not by the antagonist at the other β- adrenoceptor. Although β1-adrenoceptors are present in chick brain, they do not seem to have a role in memory formation. These results explain why noradrenaline, acting at different adrenoceptors, can have different effects on memory formation with memory being either consolidated or inhibited depending on the dose. The findings also demonstrate a role in memory formation for β3-adrenoceptors found in the brain. Agonists acting specifically at β2- or β3-adrenoceptors may be of value in diseases involving cognitive impairment.

Original languageEnglish
Pages (from-to)913-922
Number of pages10
JournalNeuroscience
Volume95
Issue number3
DOIs
Publication statusPublished - 1 Dec 1999

Keywords

  • β-and β- adrenoceptors
  • Chick
  • Discriminated avoidance learning
  • Isoprenaline
  • Labile memory
  • Noradrenaline

Cite this

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title = "Separate roles for β2- and β3-adrenoceptors in memory consolidation",
abstract = "Consolidation of a labile memory which would not normally be stored can be achieved by intracerebral administration of noradrenaline. In a series of experiments using discriminated, one trial passive avoidance learning with the day-old chick, the effect of noradrenaline has been shown to be due to actions at different subtypes of adrenoceptors. The effect of noradrenaline is dose-dependent, with a moderate dose producing memory consolidation. However, higher doses of noradrenaline (0.3-10 nmol/hemisphere) prevent consolidation, an effect not seen with isoprenaline suggesting that these doses stimulate α-adrenoceptors. The promotion of memory consolidation by noradrenaline or isoprenaline at low doses was attributable to β3- adrenoceptors and at medium doses to β2-adrenoceptors. At higher doses of noradrenaline, there was α1-adrenoceptor-mediated inhibition of memory consolidation. Consolidation can also be achieved by administration of either β2- or β3-adrenoceptor agonists at specific times after training. Although these two adrenoceptors both promoted memory consolidation, there was a differential action on the stages of memory formation. The dose- response curve to the β3- and the β2-agonists was shifted by the appropriate antagonist but not by the antagonist at the other β- adrenoceptor. Although β1-adrenoceptors are present in chick brain, they do not seem to have a role in memory formation. These results explain why noradrenaline, acting at different adrenoceptors, can have different effects on memory formation with memory being either consolidated or inhibited depending on the dose. The findings also demonstrate a role in memory formation for β3-adrenoceptors found in the brain. Agonists acting specifically at β2- or β3-adrenoceptors may be of value in diseases involving cognitive impairment.",
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Separate roles for β2- and β3-adrenoceptors in memory consolidation. / Gibbs, M. E.; Summers, R. J.

In: Neuroscience, Vol. 95, No. 3, 01.12.1999, p. 913-922.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Summers, R. J.

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KW - Isoprenaline

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