Sensory integration deficits support a dimensional view of psychosis and are not limited to schizophrenia

O. Carter, D. Bennett, T. Nash, S. Arnold, L. Brown, R. Y. Cai, Z. Allan, A. Dluzniak, K. McAnally, D. Burr, S. Sundram

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Visual dysfunction is commonplace in schizophrenia and occurs alongside cognitive, psychotic and affective symptoms of the disorder. Psychophysical evidence suggests that this dysfunction results from impairments in the integration of low-level neural signals into complex cortical representations, which may also be associated with symptom formation. Despite the symptoms of schizophrenia occurring in a range of disorders, the integration deficit has not been tested in broader patient populations. Moreover, it remains unclear whether such deficits generalize across other sensory modalities. The present study assessed patients with a range of psychotic and nonpsychotic disorders and healthy controls on visual contrast detection, visual motion integration, auditory tone detection and auditory tone integration. The sample comprised a total of 249 participants (schizophrenia spectrum disorder n = 98; bipolar affective disorder n = 35; major depression n = 31; other psychiatric conditions n = 31; and healthy controls n=54), of whom 178 completed one or more visual task and 71 completed auditory tasks. Compared with healthy controls and nonpsychotic patients, psychotic patients trans-diagnostically were impaired on both visual and auditory integration, but unimpaired in simple visual or auditory detection. Impairment in visual motion integration was correlated with the severity of positive symptoms, and could not be accounted for by a reduction in processing speed, inattention or medication effects. Our results demonstrate that impaired sensory integration is not specific to schizophrenia, as has previously been assumed. Instead, sensory deficits are closely related to the presence of positive symptoms independent of diagnosis. The finding that equivalent integrative sensory processing is impaired in audition is consistent with hypotheses that propose a generalized deficit of neural integration in psychotic disorders.

Original languageEnglish
Article numbere1118
Number of pages8
JournalTranslational Psychiatry
Volume7
Issue number5
DOIs
Publication statusPublished - 9 May 2017

Cite this

Carter, O. ; Bennett, D. ; Nash, T. ; Arnold, S. ; Brown, L. ; Cai, R. Y. ; Allan, Z. ; Dluzniak, A. ; McAnally, K. ; Burr, D. ; Sundram, S. / Sensory integration deficits support a dimensional view of psychosis and are not limited to schizophrenia. In: Translational Psychiatry. 2017 ; Vol. 7, No. 5.
@article{4988b3d533004f49a22e3bf10a9b7e0a,
title = "Sensory integration deficits support a dimensional view of psychosis and are not limited to schizophrenia",
abstract = "Visual dysfunction is commonplace in schizophrenia and occurs alongside cognitive, psychotic and affective symptoms of the disorder. Psychophysical evidence suggests that this dysfunction results from impairments in the integration of low-level neural signals into complex cortical representations, which may also be associated with symptom formation. Despite the symptoms of schizophrenia occurring in a range of disorders, the integration deficit has not been tested in broader patient populations. Moreover, it remains unclear whether such deficits generalize across other sensory modalities. The present study assessed patients with a range of psychotic and nonpsychotic disorders and healthy controls on visual contrast detection, visual motion integration, auditory tone detection and auditory tone integration. The sample comprised a total of 249 participants (schizophrenia spectrum disorder n = 98; bipolar affective disorder n = 35; major depression n = 31; other psychiatric conditions n = 31; and healthy controls n=54), of whom 178 completed one or more visual task and 71 completed auditory tasks. Compared with healthy controls and nonpsychotic patients, psychotic patients trans-diagnostically were impaired on both visual and auditory integration, but unimpaired in simple visual or auditory detection. Impairment in visual motion integration was correlated with the severity of positive symptoms, and could not be accounted for by a reduction in processing speed, inattention or medication effects. Our results demonstrate that impaired sensory integration is not specific to schizophrenia, as has previously been assumed. Instead, sensory deficits are closely related to the presence of positive symptoms independent of diagnosis. The finding that equivalent integrative sensory processing is impaired in audition is consistent with hypotheses that propose a generalized deficit of neural integration in psychotic disorders.",
author = "O. Carter and D. Bennett and T. Nash and S. Arnold and L. Brown and Cai, {R. Y.} and Z. Allan and A. Dluzniak and K. McAnally and D. Burr and S. Sundram",
year = "2017",
month = "5",
day = "9",
doi = "10.1038/tp.2017.69",
language = "English",
volume = "7",
journal = "Translational Psychiatry",
issn = "2158-3188",
publisher = "Nature Publishing Group",
number = "5",

}

Carter, O, Bennett, D, Nash, T, Arnold, S, Brown, L, Cai, RY, Allan, Z, Dluzniak, A, McAnally, K, Burr, D & Sundram, S 2017, 'Sensory integration deficits support a dimensional view of psychosis and are not limited to schizophrenia' Translational Psychiatry, vol. 7, no. 5, e1118. https://doi.org/10.1038/tp.2017.69

Sensory integration deficits support a dimensional view of psychosis and are not limited to schizophrenia. / Carter, O.; Bennett, D.; Nash, T.; Arnold, S.; Brown, L.; Cai, R. Y.; Allan, Z.; Dluzniak, A.; McAnally, K.; Burr, D.; Sundram, S.

In: Translational Psychiatry, Vol. 7, No. 5, e1118, 09.05.2017.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Sensory integration deficits support a dimensional view of psychosis and are not limited to schizophrenia

AU - Carter, O.

AU - Bennett, D.

AU - Nash, T.

AU - Arnold, S.

AU - Brown, L.

AU - Cai, R. Y.

AU - Allan, Z.

AU - Dluzniak, A.

AU - McAnally, K.

AU - Burr, D.

AU - Sundram, S.

PY - 2017/5/9

Y1 - 2017/5/9

N2 - Visual dysfunction is commonplace in schizophrenia and occurs alongside cognitive, psychotic and affective symptoms of the disorder. Psychophysical evidence suggests that this dysfunction results from impairments in the integration of low-level neural signals into complex cortical representations, which may also be associated with symptom formation. Despite the symptoms of schizophrenia occurring in a range of disorders, the integration deficit has not been tested in broader patient populations. Moreover, it remains unclear whether such deficits generalize across other sensory modalities. The present study assessed patients with a range of psychotic and nonpsychotic disorders and healthy controls on visual contrast detection, visual motion integration, auditory tone detection and auditory tone integration. The sample comprised a total of 249 participants (schizophrenia spectrum disorder n = 98; bipolar affective disorder n = 35; major depression n = 31; other psychiatric conditions n = 31; and healthy controls n=54), of whom 178 completed one or more visual task and 71 completed auditory tasks. Compared with healthy controls and nonpsychotic patients, psychotic patients trans-diagnostically were impaired on both visual and auditory integration, but unimpaired in simple visual or auditory detection. Impairment in visual motion integration was correlated with the severity of positive symptoms, and could not be accounted for by a reduction in processing speed, inattention or medication effects. Our results demonstrate that impaired sensory integration is not specific to schizophrenia, as has previously been assumed. Instead, sensory deficits are closely related to the presence of positive symptoms independent of diagnosis. The finding that equivalent integrative sensory processing is impaired in audition is consistent with hypotheses that propose a generalized deficit of neural integration in psychotic disorders.

AB - Visual dysfunction is commonplace in schizophrenia and occurs alongside cognitive, psychotic and affective symptoms of the disorder. Psychophysical evidence suggests that this dysfunction results from impairments in the integration of low-level neural signals into complex cortical representations, which may also be associated with symptom formation. Despite the symptoms of schizophrenia occurring in a range of disorders, the integration deficit has not been tested in broader patient populations. Moreover, it remains unclear whether such deficits generalize across other sensory modalities. The present study assessed patients with a range of psychotic and nonpsychotic disorders and healthy controls on visual contrast detection, visual motion integration, auditory tone detection and auditory tone integration. The sample comprised a total of 249 participants (schizophrenia spectrum disorder n = 98; bipolar affective disorder n = 35; major depression n = 31; other psychiatric conditions n = 31; and healthy controls n=54), of whom 178 completed one or more visual task and 71 completed auditory tasks. Compared with healthy controls and nonpsychotic patients, psychotic patients trans-diagnostically were impaired on both visual and auditory integration, but unimpaired in simple visual or auditory detection. Impairment in visual motion integration was correlated with the severity of positive symptoms, and could not be accounted for by a reduction in processing speed, inattention or medication effects. Our results demonstrate that impaired sensory integration is not specific to schizophrenia, as has previously been assumed. Instead, sensory deficits are closely related to the presence of positive symptoms independent of diagnosis. The finding that equivalent integrative sensory processing is impaired in audition is consistent with hypotheses that propose a generalized deficit of neural integration in psychotic disorders.

UR - http://www.scopus.com/inward/record.url?scp=85038927522&partnerID=8YFLogxK

U2 - 10.1038/tp.2017.69

DO - 10.1038/tp.2017.69

M3 - Article

VL - 7

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

IS - 5

M1 - e1118

ER -