Semi-automated multi-dimensional characterization of synthetic copolymers

Sarah Crotty; Christine Weber; Anja Baumgaertel; Nicole Fritz; Esra Altuntaş; Kristian Kempe; Ulrich S. Schubert

doi:10.1016/j.eurpolymj.2014.07.030

Semi-automated multi-dimensional characterization of synthetic copolymers

Sarah Crotty
, Christine Weber
, Anja Baumgaertel
, Nicole Fritz
, Esra Altuntaş
, Kristian Kempe
, Ulrich S. Schubert

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

Multi-dimensional high-throughput approaches are being transferred from biological to synthetic polymer systems due to the important increase of applications of polymers in life science. As a result, automated robotic spotting of poly(2-ethyl-2-oxazoline)s p(EtOx) was performed for the first time in combination with liquid adsorption chromatography at critical conditions (LACCC) and furthermore exploited for p(EtOx) block copolymers prepared for application as drug delivery systems. The LACCC is a complex and time-consuming process however, extremely helpful for the identification of the chemical functionality of polymers. The hyphenation between HPLC-MALDI-ToF MS via spotting and the subsequent analysis by ESI-Q-ToF MS/MS enabled the detailed characterization of side products occurring during the synthesis.

Original language	English
Pages (from-to)	153-162
Number of pages	10
Journal	European Polymer Journal
Volume	60
DOIs	https://doi.org/10.1016/j.eurpolymj.2014.07.030
Publication status	Published - 2014
Externally published	Yes

Keywords

Automated robotic spotting
critical conditions (LACCC)
ESI-Q-ToF-MS
Liquid adsorption chromatography under
MALDI-ToF MS
Poly(2-oxazoline)s

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10.1016/j.eurpolymj.2014.07.030

Cite this

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title = "Semi-automated multi-dimensional characterization of synthetic copolymers",

abstract = "Multi-dimensional high-throughput approaches are being transferred from biological to synthetic polymer systems due to the important increase of applications of polymers in life science. As a result, automated robotic spotting of poly(2-ethyl-2-oxazoline)s p(EtOx) was performed for the first time in combination with liquid adsorption chromatography at critical conditions (LACCC) and furthermore exploited for p(EtOx) block copolymers prepared for application as drug delivery systems. The LACCC is a complex and time-consuming process however, extremely helpful for the identification of the chemical functionality of polymers. The hyphenation between HPLC-MALDI-ToF MS via spotting and the subsequent analysis by ESI-Q-ToF MS/MS enabled the detailed characterization of side products occurring during the synthesis.",

keywords = "Automated robotic spotting, critical conditions (LACCC), ESI-Q-ToF-MS, Liquid adsorption chromatography under, MALDI-ToF MS, Poly(2-oxazoline)s",

author = "Sarah Crotty and Christine Weber and Anja Baumgaertel and Nicole Fritz and Esra Altunta{\c s} and Kristian Kempe and Schubert, \{Ulrich S.\}",

year = "2014",

doi = "10.1016/j.eurpolymj.2014.07.030",

language = "English",

volume = "60",

pages = "153--162",

journal = "European Polymer Journal",

issn = "0014-3057",

publisher = "Elsevier",

}

TY - JOUR

T1 - Semi-automated multi-dimensional characterization of synthetic copolymers

AU - Crotty, Sarah

AU - Weber, Christine

AU - Baumgaertel, Anja

AU - Fritz, Nicole

AU - Altuntaş, Esra

AU - Kempe, Kristian

AU - Schubert, Ulrich S.

PY - 2014

Y1 - 2014

N2 - Multi-dimensional high-throughput approaches are being transferred from biological to synthetic polymer systems due to the important increase of applications of polymers in life science. As a result, automated robotic spotting of poly(2-ethyl-2-oxazoline)s p(EtOx) was performed for the first time in combination with liquid adsorption chromatography at critical conditions (LACCC) and furthermore exploited for p(EtOx) block copolymers prepared for application as drug delivery systems. The LACCC is a complex and time-consuming process however, extremely helpful for the identification of the chemical functionality of polymers. The hyphenation between HPLC-MALDI-ToF MS via spotting and the subsequent analysis by ESI-Q-ToF MS/MS enabled the detailed characterization of side products occurring during the synthesis.

AB - Multi-dimensional high-throughput approaches are being transferred from biological to synthetic polymer systems due to the important increase of applications of polymers in life science. As a result, automated robotic spotting of poly(2-ethyl-2-oxazoline)s p(EtOx) was performed for the first time in combination with liquid adsorption chromatography at critical conditions (LACCC) and furthermore exploited for p(EtOx) block copolymers prepared for application as drug delivery systems. The LACCC is a complex and time-consuming process however, extremely helpful for the identification of the chemical functionality of polymers. The hyphenation between HPLC-MALDI-ToF MS via spotting and the subsequent analysis by ESI-Q-ToF MS/MS enabled the detailed characterization of side products occurring during the synthesis.

KW - Automated robotic spotting

KW - critical conditions (LACCC)

KW - ESI-Q-ToF-MS

KW - Liquid adsorption chromatography under

KW - MALDI-ToF MS

KW - Poly(2-oxazoline)s

UR - https://www.scopus.com/pages/publications/84907797301

U2 - 10.1016/j.eurpolymj.2014.07.030

DO - 10.1016/j.eurpolymj.2014.07.030

M3 - Article

AN - SCOPUS:84907797301

SN - 0014-3057

VL - 60

SP - 153

EP - 162

JO - European Polymer Journal

JF - European Polymer Journal

ER -

Semi-automated multi-dimensional characterization of synthetic copolymers

Abstract

Keywords

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