Self-emulsifying drug delivery systems

assessment of the efficiency of emulsification

Research output: Contribution to journalArticleResearchpeer-review

216 Citations (Scopus)

Abstract

Self-emulsifying formulations have potential uses as vehicles for the administration of lipophilic drugs by the oral route. In this study model oil-surfactant mixtures were allowed to self-emulsify under conditions of gentle agitation. During emulsification the relative intensity of light scattered by the dispersion was monitored continuously which enabled the rates of emulsification to be compared. The particle sizes of resultant emulsions were compared by light microscopy and using a Coulter Nano-Sizer. Efficient self-emulsifying formulations were produced by the oils Miglyol 812 or Miglyol 840 in combination with the surfactant Tween 85. The properties of these systems have been studied over a range of mixture compositions. The finest dispersions were produced rapidly and in reproducible time by a mixture of 30% w/w Tween 85 and 70% w/w Miglyol 812.

Original languageEnglish
Pages (from-to)335-348
Number of pages14
JournalInternational Journal of Pharmaceutics
Volume27
Issue number2-3
DOIs
Publication statusPublished - 1 Jan 1985

Keywords

  • drug delivery
  • emulsification rate
  • non-ionic surfactant
  • particle size
  • self-emulsification

Cite this

@article{bb32cda1cd22452ebe7c144648aec83c,
title = "Self-emulsifying drug delivery systems: assessment of the efficiency of emulsification",
abstract = "Self-emulsifying formulations have potential uses as vehicles for the administration of lipophilic drugs by the oral route. In this study model oil-surfactant mixtures were allowed to self-emulsify under conditions of gentle agitation. During emulsification the relative intensity of light scattered by the dispersion was monitored continuously which enabled the rates of emulsification to be compared. The particle sizes of resultant emulsions were compared by light microscopy and using a Coulter Nano-Sizer. Efficient self-emulsifying formulations were produced by the oils Miglyol 812 or Miglyol 840 in combination with the surfactant Tween 85. The properties of these systems have been studied over a range of mixture compositions. The finest dispersions were produced rapidly and in reproducible time by a mixture of 30{\%} w/w Tween 85 and 70{\%} w/w Miglyol 812.",
keywords = "drug delivery, emulsification rate, non-ionic surfactant, particle size, self-emulsification",
author = "Pouton, {Colin W.}",
year = "1985",
month = "1",
day = "1",
doi = "10.1016/0378-5173(85)90081-X",
language = "English",
volume = "27",
pages = "335--348",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "2-3",

}

Self-emulsifying drug delivery systems : assessment of the efficiency of emulsification. / Pouton, Colin W.

In: International Journal of Pharmaceutics, Vol. 27, No. 2-3, 01.01.1985, p. 335-348.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Self-emulsifying drug delivery systems

T2 - assessment of the efficiency of emulsification

AU - Pouton, Colin W.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - Self-emulsifying formulations have potential uses as vehicles for the administration of lipophilic drugs by the oral route. In this study model oil-surfactant mixtures were allowed to self-emulsify under conditions of gentle agitation. During emulsification the relative intensity of light scattered by the dispersion was monitored continuously which enabled the rates of emulsification to be compared. The particle sizes of resultant emulsions were compared by light microscopy and using a Coulter Nano-Sizer. Efficient self-emulsifying formulations were produced by the oils Miglyol 812 or Miglyol 840 in combination with the surfactant Tween 85. The properties of these systems have been studied over a range of mixture compositions. The finest dispersions were produced rapidly and in reproducible time by a mixture of 30% w/w Tween 85 and 70% w/w Miglyol 812.

AB - Self-emulsifying formulations have potential uses as vehicles for the administration of lipophilic drugs by the oral route. In this study model oil-surfactant mixtures were allowed to self-emulsify under conditions of gentle agitation. During emulsification the relative intensity of light scattered by the dispersion was monitored continuously which enabled the rates of emulsification to be compared. The particle sizes of resultant emulsions were compared by light microscopy and using a Coulter Nano-Sizer. Efficient self-emulsifying formulations were produced by the oils Miglyol 812 or Miglyol 840 in combination with the surfactant Tween 85. The properties of these systems have been studied over a range of mixture compositions. The finest dispersions were produced rapidly and in reproducible time by a mixture of 30% w/w Tween 85 and 70% w/w Miglyol 812.

KW - drug delivery

KW - emulsification rate

KW - non-ionic surfactant

KW - particle size

KW - self-emulsification

UR - http://www.scopus.com/inward/record.url?scp=0022366625&partnerID=8YFLogxK

U2 - 10.1016/0378-5173(85)90081-X

DO - 10.1016/0378-5173(85)90081-X

M3 - Article

VL - 27

SP - 335

EP - 348

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 2-3

ER -