Self-assembly of trifunctional tripeptides to form neural scaffolds

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Abstract

Peptide self-assembly has been exploited to generate a multitude of biomaterials that exhibit biocompatibility due to their similarity to naturally occurring proteins. Previously, we have shown that β-tripeptides self-assemble despite containing sterically bulky, functional sidechains. Herein, we describe the synthesis of a novel β-amino acid to allow for the synthesis of a trifunctional β-tripeptide that remarkably maintains self-assembly and acts as a bioactive neuronal scaffold. These scaffolds show promise for studies involving neuronal cell growth and development.

Original languageEnglish
Pages (from-to)4475-4479
Number of pages5
JournalJournal of Materials Chemistry B
Volume9
Issue number22
DOIs
Publication statusPublished - 14 Jun 2021

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