Self-assembling macromolecular chimeras: controlling fibrillization of a β-sheet forming peptide by polymer conjugation

Hamilton Kakwere, Richard J. Payne, Katrina A Jolliffe, Sébastien Perrier

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Water soluble poly(hydroxyethyl acrylate) [P(HEA)] polymers were successfully conjugated to an azide functionalized β-sheet forming peptide (P11-2) to form macromolecular chimeras using Cu(i) catalyzed azide-alkyne cycloaddition ('click') chemistry. We found that the β-sheet formation and hence fibrillization tendency of P11-2 was severely diminished by P(HEA) conjugation. Moreover chimeras were observed to inhibit fibrillization when added to a pure β-sheet forming peptide. 

Original languageEnglish
Pages (from-to)3754-3757
Number of pages4
JournalSoft Matter
Issue number8
Publication statusPublished - 21 Apr 2011
Externally publishedYes

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