Self-assembling injectable peptide hydrogels for emerging treatment of ischemic stroke

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Ischaemic stroke remains one of the leading causes of death and disability worldwide, without any long-term effective treatments targeted at regeneration. Limitations of existing and proposed cell- and drug-based therapies have led to the investigation of hydrogel-based strategies for new and improved therapies. They aim to enhance the intrinsic repair mechanisms, improve engraftment of therapeutic stem cells, and deliver drugs/biologics in a controlled manner in the post-stroke brain. The following article will explore the pathophysiology of stroke, and the need for injectable hydrogels in neural tissue engineering, focusing on a class of injectable hydrogels based on self-assembling peptides (SAPs). The various types of these materials will be addressed based on their mechanisms of self-assembly, including their novelties and benefits over conventional hydrogels, as well as recent experimental research that demonstrates the potential of these biomaterials in the treatment of stroke.

Original languageEnglish
Pages (from-to)3927-3943
Number of pages17
JournalJournal of Materials Chemistry B
Volume7
Issue number25
DOIs
Publication statusPublished - 2019

Cite this

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title = "Self-assembling injectable peptide hydrogels for emerging treatment of ischemic stroke",
abstract = "Ischaemic stroke remains one of the leading causes of death and disability worldwide, without any long-term effective treatments targeted at regeneration. Limitations of existing and proposed cell- and drug-based therapies have led to the investigation of hydrogel-based strategies for new and improved therapies. They aim to enhance the intrinsic repair mechanisms, improve engraftment of therapeutic stem cells, and deliver drugs/biologics in a controlled manner in the post-stroke brain. The following article will explore the pathophysiology of stroke, and the need for injectable hydrogels in neural tissue engineering, focusing on a class of injectable hydrogels based on self-assembling peptides (SAPs). The various types of these materials will be addressed based on their mechanisms of self-assembly, including their novelties and benefits over conventional hydrogels, as well as recent experimental research that demonstrates the potential of these biomaterials in the treatment of stroke.",
author = "Andrew Hong and Marie-Isabel Aguilar and {Del Borgo}, {Mark P.} and Sobey, {Christopher G.} and Broughton, {Brad R. S.} and Forsythe, {John S.}",
year = "2019",
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publisher = "The Royal Society of Chemistry",
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AU - Hong, Andrew

AU - Aguilar, Marie-Isabel

AU - Del Borgo, Mark P.

AU - Sobey, Christopher G.

AU - Broughton, Brad R. S.

AU - Forsythe, John S.

PY - 2019

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AB - Ischaemic stroke remains one of the leading causes of death and disability worldwide, without any long-term effective treatments targeted at regeneration. Limitations of existing and proposed cell- and drug-based therapies have led to the investigation of hydrogel-based strategies for new and improved therapies. They aim to enhance the intrinsic repair mechanisms, improve engraftment of therapeutic stem cells, and deliver drugs/biologics in a controlled manner in the post-stroke brain. The following article will explore the pathophysiology of stroke, and the need for injectable hydrogels in neural tissue engineering, focusing on a class of injectable hydrogels based on self-assembling peptides (SAPs). The various types of these materials will be addressed based on their mechanisms of self-assembly, including their novelties and benefits over conventional hydrogels, as well as recent experimental research that demonstrates the potential of these biomaterials in the treatment of stroke.

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U2 - 10.1039/c9tb00257j

DO - 10.1039/c9tb00257j

M3 - Review Article

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JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

SN - 2050-750X

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ER -