Abstract
Ischaemic stroke remains one of the leading causes of death and disability worldwide, without any long-term effective treatments targeted at regeneration. Limitations of existing and proposed cell- and drug-based therapies have led to the investigation of hydrogel-based strategies for new and improved therapies. They aim to enhance the intrinsic repair mechanisms, improve engraftment of therapeutic stem cells, and deliver drugs/biologics in a controlled manner in the post-stroke brain. The following article will explore the pathophysiology of stroke, and the need for injectable hydrogels in neural tissue engineering, focusing on a class of injectable hydrogels based on self-assembling peptides (SAPs). The various types of these materials will be addressed based on their mechanisms of self-assembly, including their novelties and benefits over conventional hydrogels, as well as recent experimental research that demonstrates the potential of these biomaterials in the treatment of stroke.
| Original language | English |
|---|---|
| Pages (from-to) | 3927-3943 |
| Number of pages | 17 |
| Journal | Journal of Materials Chemistry B |
| Volume | 7 |
| Issue number | 25 |
| DOIs | |
| Publication status | Published - 2019 |
Cite this
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Self-assembling injectable peptide hydrogels for emerging treatment of ischemic stroke. / Hong, Andrew; Aguilar, Marie-Isabel; Del Borgo, Mark P.; Sobey, Christopher G.; Broughton, Brad R. S.; Forsythe, John S.
In: Journal of Materials Chemistry B, Vol. 7, No. 25, 2019, p. 3927-3943.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - Self-assembling injectable peptide hydrogels for emerging treatment of ischemic stroke
AU - Hong, Andrew
AU - Aguilar, Marie-Isabel
AU - Del Borgo, Mark P.
AU - Sobey, Christopher G.
AU - Broughton, Brad R. S.
AU - Forsythe, John S.
PY - 2019
Y1 - 2019
N2 - Ischaemic stroke remains one of the leading causes of death and disability worldwide, without any long-term effective treatments targeted at regeneration. Limitations of existing and proposed cell- and drug-based therapies have led to the investigation of hydrogel-based strategies for new and improved therapies. They aim to enhance the intrinsic repair mechanisms, improve engraftment of therapeutic stem cells, and deliver drugs/biologics in a controlled manner in the post-stroke brain. The following article will explore the pathophysiology of stroke, and the need for injectable hydrogels in neural tissue engineering, focusing on a class of injectable hydrogels based on self-assembling peptides (SAPs). The various types of these materials will be addressed based on their mechanisms of self-assembly, including their novelties and benefits over conventional hydrogels, as well as recent experimental research that demonstrates the potential of these biomaterials in the treatment of stroke.
AB - Ischaemic stroke remains one of the leading causes of death and disability worldwide, without any long-term effective treatments targeted at regeneration. Limitations of existing and proposed cell- and drug-based therapies have led to the investigation of hydrogel-based strategies for new and improved therapies. They aim to enhance the intrinsic repair mechanisms, improve engraftment of therapeutic stem cells, and deliver drugs/biologics in a controlled manner in the post-stroke brain. The following article will explore the pathophysiology of stroke, and the need for injectable hydrogels in neural tissue engineering, focusing on a class of injectable hydrogels based on self-assembling peptides (SAPs). The various types of these materials will be addressed based on their mechanisms of self-assembly, including their novelties and benefits over conventional hydrogels, as well as recent experimental research that demonstrates the potential of these biomaterials in the treatment of stroke.
UR - http://www.scopus.com/inward/record.url?scp=85068105656&partnerID=8YFLogxK
U2 - 10.1039/c9tb00257j
DO - 10.1039/c9tb00257j
M3 - Review Article
VL - 7
SP - 3927
EP - 3943
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
SN - 2050-750X
IS - 25
ER -