Self-Assembled Nanoparticles from Phenolic Derivatives for Cancer Therapy

Yunlu Dai, Junling Guo, Ting Yi Wang, Yi Ju, Andrew J. Mitchell, Thomas Bonnard, Jiwei Cui, Joseph J. Richardson, Christoph E. Hagemeyer, Karen Alt, Frank Caruso

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Abstract

Therapeutic nanoparticles hold clinical promise for cancer treatment by avoiding limitations of conventional pharmaceuticals. Herein, a facile and rapid method is introduced to assemble poly(ethylene glycol) (PEG)-modified Pt prodrug nanocomplexes through metal-polyphenol complexation and combined with emulsification, which results in ≈100 nm diameter nanoparticles (PtP NPs) that exhibit high drug loading (0.15 fg Pt per nanoparticle) and low fouling properties. The PtP NPs are characterized for potential use as cancer therapeutics. Mass cytometry is used to quantify uptake of the nanoparticles and the drug concentration in individual cells in vitro. The PtP NPs have long circulation times, with an elimination half-life of ≈18 h in healthy mice. The in vivo antitumor activity of the PtP NPs is systematically investigated in a human prostate cancer xenograft mouse model. Mice treated with the PtP NPs demonstrate four times better inhibition of tumor growth than either free prodrug or cisplatin. This study presents a promising strategy to prepare therapeutic nanoparticles for biomedical applications.

Original languageEnglish
Article number1700467
Number of pages7
JournalAdvanced Healthcare Materials
Volume6
Issue number16
DOIs
Publication statusPublished - 23 Aug 2017

Keywords

  • Nanoparticles
  • Platinum prodrugs
  • Polyphenols
  • Self-assembly
  • Tumor therapy

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