Self-assembled nanocube-based plasmene nanosheets as soft surface-enhanced raman scattering substrates toward direct quantitative drug identification on surfaces

Kae Jye Si; Pengzhen Guo; Qianqian Shi; Wenlong Cheng

doi:10.1021/acs.analchem.5b00328

Self-assembled nanocube-based plasmene nanosheets as soft surface-enhanced raman scattering substrates toward direct quantitative drug identification on surfaces

Kae Jye Si, Pengzhen Guo, Qianqian Shi, Wenlong Cheng

Chemical Engineering

Research output: Contribution to journal › Article › Research › peer-review

Abstract

We report on self-assembled nanocube-based plasmene nanosheets as new surface-enhanced Raman scattering (SERS) substrates toward direct identification of a trace amount of drugs sitting on topologically complex real-world surfaces. The uniform nanocube arrays (superlattices) led to low spatial SERS signal variances ( 2 ). Unlike conventional SERS substrates which are based on rigid nanostructured metals, our plasmene nanosheets are mechanically soft and optically semitransparent, enabling conformal attachment to real-world solid surfaces such as banknotes for direct SERS identification of drugs. Our plasmene nanosheets were able to detect benzocaine overdose down to a parts-per-billion (ppb) level with an excellent linear relationship (R2 > 0.99) between characteristic peak intensity and concentration. On banknote surfaces, a detection limit of 0.9 ? 10-6 g/cm2 benzocaine could be achieved. Furthermore, a few other drugs could also be identified, even in their binary mixtures with our plasmene nanosheets. Our experimental results clearly show that our plasmene sheets represent a new class of unique SERS substrates, potentially serving as a versatile platform for real-world forensic drug identification.

Original language	English
Pages (from-to)	5263 - 5269
Number of pages	7
Journal	Analytical Chemistry
Volume	87
Issue number	10
DOIs	https://doi.org/10.1021/acs.analchem.5b00328
Publication status	Published - 2015

Cite this

Si, K. J., Guo, P., Shi, Q., & Cheng, W. (2015). Self-assembled nanocube-based plasmene nanosheets as soft surface-enhanced raman scattering substrates toward direct quantitative drug identification on surfaces. Analytical Chemistry, 87(10), 5263 - 5269. https://doi.org/10.1021/acs.analchem.5b00328

Si, Kae Jye ; Guo, Pengzhen ; Shi, Qianqian ; Cheng, Wenlong. / Self-assembled nanocube-based plasmene nanosheets as soft surface-enhanced raman scattering substrates toward direct quantitative drug identification on surfaces. In: Analytical Chemistry. 2015 ; Vol. 87, No. 10. pp. 5263 - 5269.

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title = "Self-assembled nanocube-based plasmene nanosheets as soft surface-enhanced raman scattering substrates toward direct quantitative drug identification on surfaces",

abstract = "We report on self-assembled nanocube-based plasmene nanosheets as new surface-enhanced Raman scattering (SERS) substrates toward direct identification of a trace amount of drugs sitting on topologically complex real-world surfaces. The uniform nanocube arrays (superlattices) led to low spatial SERS signal variances ( 2 ). Unlike conventional SERS substrates which are based on rigid nanostructured metals, our plasmene nanosheets are mechanically soft and optically semitransparent, enabling conformal attachment to real-world solid surfaces such as banknotes for direct SERS identification of drugs. Our plasmene nanosheets were able to detect benzocaine overdose down to a parts-per-billion (ppb) level with an excellent linear relationship (R2 > 0.99) between characteristic peak intensity and concentration. On banknote surfaces, a detection limit of 0.9 ? 10-6 g/cm2 benzocaine could be achieved. Furthermore, a few other drugs could also be identified, even in their binary mixtures with our plasmene nanosheets. Our experimental results clearly show that our plasmene sheets represent a new class of unique SERS substrates, potentially serving as a versatile platform for real-world forensic drug identification.",

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Si, KJ, Guo, P, Shi, Q & Cheng, W 2015, 'Self-assembled nanocube-based plasmene nanosheets as soft surface-enhanced raman scattering substrates toward direct quantitative drug identification on surfaces', Analytical Chemistry, vol. 87, no. 10, pp. 5263 - 5269. https://doi.org/10.1021/acs.analchem.5b00328

Self-assembled nanocube-based plasmene nanosheets as soft surface-enhanced raman scattering substrates toward direct quantitative drug identification on surfaces. / Si, Kae Jye; Guo, Pengzhen; Shi, Qianqian; Cheng, Wenlong.

In: Analytical Chemistry, Vol. 87, No. 10, 2015, p. 5263 - 5269.

Research output: Contribution to journal › Article › Research › peer-review

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