Selenium and Alzheimer’s disease

Adriana Gisele Hertzog da Silva Leme, Barbara R Cardoso

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

Abstract

Selenium is an essential micronutrient to mammals and plays its role through selenoproteins characterized by the presence of the 21st amino acid selenocysteine. Although these proteins are of low abundance in the brain, they participate in different mechanisms required for brain homeostasis, such as neutralization of reactive oxygen species and modulation of Ca2+ channels and mitochondrial function. Selenium has been identified as playing a role against Alzheimer's disease by minimizing amyloid β aggregation, hyperphosphorylation of tau protein, and preventing neuronal death. This chapter discusses the current literature investigating how selenium may be involved in Alzheimer's disease pathogenesis.
Original languageEnglish
Title of host publicationGenetics, Neurology, Behavior, and Diet in Dementia
Subtitle of host publicationThe Neuroscience of Dementia
EditorsColin R. Martin, Victor R. Preedy
Place of PublicationUnited Kingdom
PublisherAcademic Press
Chapter47
Pages739-748
Number of pages10
Volume2
Edition1st
ISBN (Print)9780128158685
DOIs
Publication statusPublished - 2020
Externally publishedYes

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