Selectivity optimisation of biomimetic molecularly imprinted polymer thin films

Reinhard I Boysen, Shuyan Li, Jamil Chowdhury, Lachlan Schwarz, Milton Thomas William Hearn

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4 Citations (Scopus)


This study describes the design and synthesis of molecularly imprinted polymers (MIPs) as patterned thin films, based on molecular modelling of functional monomer-template interactions and validation by NMR-spectroscopy. MIPs were prepared by dissolving the specific template and functional methacrylate monomer at varying ratios with a cross-linker and initiator in a porogenic solvent, spin-coating the solution onto 3-(trimethoxysilyl)propyl methacrylate-functionalised silicon wafers and photo-polymerisation. After template extraction, the film thickness and topography were characterised with atomic force microscopy. A 4-vinylpyridine-MIP thin film layer was then deposited by photo-lithographic etching onto this polymerised methacrylic acid MIP thin film, resulting in a grid-patterned surface in which two different MIPs alternated at a micron scale. Selectivity differences towards fluorescent template analogues were documented using fluorescence microscopy. This side-by-side comparison on the same thin film allows fast and cost-effective assessment of MIP selectivities with various biomolecules.
Original languageEnglish
Pages (from-to)81 - 84
Number of pages4
JournalMicroelectronic Engineering
Publication statusPublished - 2012

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