Selectivity of a series of clonidine-like drugs for α1 and α2 adrenoceptors in rat brain

R. J. Summers, B. Jarrott, W. J. Louis

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Abstract

The relative selectivity of a series of imidazoline derivatives and substituted guanidines structurally related to clonidine for α1 and α2 adrenoceptors has been examined in binding studies using membranes prepared from rat cerebral cortex and the radioligands [3H]prazosin and [3H]clonidine. There was a 150-fold difference between the most and least selective clonidine-like drugs in their relative affinity for α1 and α2 adrenoceptors.

Original languageEnglish
Pages (from-to)347-350
Number of pages4
JournalNeuroscience Letters
Volume20
Issue number3
DOIs
Publication statusPublished - 1 Jan 1980

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