Selective spatial processing deficits in an at-risk subgroup of the fragile X premutation

Darren Robert Hocking, Cary S Kogan, Kim Marie Cornish

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30 Citations (Scopus)


Until a decade ago, it was assumed that males with the fragile X premutation were unaffected by any cognitive phenotype. Here we examined the extent to which CGG repeat toxicity extends to visuospatial functioning in male fragile X premutation carriers who are asymptomatic for a late-onset neurodegenerative disorder, fragile X-associated tremor/ataxia syndrome (FXTAS). Thirty-three premutation males aged 20?68 years [divided into two groups: 16 low-repeat carriers (CGG ? 55? <100) and 17 high-repeat carriers (CGG > 100)] with a family history of fragile X syndrome and 62 non-affected adult males with normal FMR1 alleles were recruited
Original languageEnglish
Pages (from-to)39 - 44
Number of pages6
JournalBrain and Cognition
Issue number1
Publication statusPublished - 2012

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