Selective sequence for the peptide-triggered phase transition of lyotropic liquid-crystalline structures

Qingtao Liu, Yao-Da Dong, Ben J. Boyd

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

A novel concept of using mixed lipids to construct selective peptide-sequence-sensing lyotropic liquid-crystalline (LLC) dispersion systems was investigated. The LLC systems were constructed using a mixture of phytantriol, a lipid that forms lyotropic liquid-crystalline phases, and a novel synthesized peptide-lipid (peplipid) for sensing a target peptide with the RARAR sequence. The internal structure of the dispersed LLC particles was converted from the lamellar structure (liposomes) to the inverse bicontinuous cubic phase (cubosomes) in the presence of the target peptide. The addition of common human proteins did not induce any structural change, indicating a high selectivity of interaction with the target peptide. The concept has potential for the design of targeted controlled release drug delivery agents.
Original languageEnglish
Pages (from-to)5155-5161
Number of pages7
JournalLangmuir
Volume32
Issue number20
DOIs
Publication statusPublished - 24 May 2016

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