TY - JOUR
T1 - Selective inhibition of the induction phase of delayed type hypersensitivity in mice by niridazole
AU - Vadas, M. A.
AU - Bernard, C. C A
PY - 1981
Y1 - 1981
N2 - Niridazole, a nitrothiazole derivative, used in the treatment of schistosomiasis, inhibits cell-mediated immunity in mice. The drug depressed delayed type hypersensitivity (DTH)3 3 Abbreviations used: CMI, cell-mediated immunity; DTH, delayed type hypersensitivity; FGG, fowl gamma globulin; KLH, keyhole limpet haemocyanin; POL, polymerized bacteria flagellin; NIP, 4-hydroxy-3-iodo-5-nitrophenylacetic acid; PFC, plaque-forming cells. when administered at the time of sensitization, and lymph node cells from niridazole-treated mice were found to be less efficient than cells from untreated controls in transferring DTH, or in providing helper function in a plaque-forming cell assay. In contrast, the drug was unable to prevent passive sensitization when given to the recipient of sensitized cells. These studies suggest that niridazole inhibits cell-mediated immune responses primarily by interfering with the afferent arm of T-cell sensitization.
AB - Niridazole, a nitrothiazole derivative, used in the treatment of schistosomiasis, inhibits cell-mediated immunity in mice. The drug depressed delayed type hypersensitivity (DTH)3 3 Abbreviations used: CMI, cell-mediated immunity; DTH, delayed type hypersensitivity; FGG, fowl gamma globulin; KLH, keyhole limpet haemocyanin; POL, polymerized bacteria flagellin; NIP, 4-hydroxy-3-iodo-5-nitrophenylacetic acid; PFC, plaque-forming cells. when administered at the time of sensitization, and lymph node cells from niridazole-treated mice were found to be less efficient than cells from untreated controls in transferring DTH, or in providing helper function in a plaque-forming cell assay. In contrast, the drug was unable to prevent passive sensitization when given to the recipient of sensitized cells. These studies suggest that niridazole inhibits cell-mediated immune responses primarily by interfering with the afferent arm of T-cell sensitization.
UR - http://www.scopus.com/inward/record.url?scp=0019415504&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(81)90141-0
DO - 10.1016/0090-1229(81)90141-0
M3 - Article
C2 - 6210477
AN - SCOPUS:0019415504
VL - 20
SP - 313
EP - 320
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
SN - 0090-1229
IS - 3
ER -