We highlight a fundamental difference between voxel-based methods that interrogate signal intensity directly and those that interrogate morphometric features; we discuss how signal intensity changes might erroneously affect morphometric measures, and we provide some guidance for selection of appropriate methods to address particular hyphotheses. Our discussion is motivated by a recent application of voxel-based morphometry methods to T2-weighted images (T2-Voxel Based Morphometry; T2-VBM). In this context we discuss alternative approaches including Voxel-Based T2-Relaxometry (VBR) and Voxel Based Iterative Sensitivity analysis of T2-Weighted Images (VBIS-T2).
- T2-Voxel based morphometry (T2-VBM)
- Voxel based iterative sensitivity analysis of T2-weighted images (VBIS-T2)
- Voxel based morphometry (VBM)
- Voxel-based T2-relaxometry (VBR)