Selecting appropriate voxel-based methods for neuroimaging studies

David F. Abbott, Gaby S. Pell, Heath R. Pardoe, Graeme D. Jackson

Research output: Contribution to journalComment / DebateOtherpeer-review

6 Citations (Scopus)


We highlight a fundamental difference between voxel-based methods that interrogate signal intensity directly and those that interrogate morphometric features; we discuss how signal intensity changes might erroneously affect morphometric measures, and we provide some guidance for selection of appropriate methods to address particular hyphotheses. Our discussion is motivated by a recent application of voxel-based morphometry methods to T2-weighted images (T2-Voxel Based Morphometry; T2-VBM). In this context we discuss alternative approaches including Voxel-Based T2-Relaxometry (VBR) and Voxel Based Iterative Sensitivity analysis of T2-Weighted Images (VBIS-T2).

Original languageEnglish
Pages (from-to)885-886
Number of pages2
Issue number2
Publication statusPublished - 16 Jan 2012
Externally publishedYes


  • T2-Voxel based morphometry (T2-VBM)
  • Voxel based iterative sensitivity analysis of T2-weighted images (VBIS-T2)
  • Voxel based morphometry (VBM)
  • Voxel-based T2-relaxometry (VBR)

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