Seizure susceptibility prediction in uncontrolled epilepsy

Nhan Duy Truong, Yikai Yang, Christina Maher, Levin Kuhlmann, Alistair McEwan, Armin Nikpour, Omid Kavehei

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Epileptic seizure forecasting, combined with the delivery of preventative therapies, holds the potential to greatly improve the quality of life for epilepsy patients and their caregivers. Forecasting seizures could prevent some potentially catastrophic consequences such as injury and death in addition to several potential clinical benefits it may provide for patient care in hospitals. The challenge of seizure forecasting lies within the seemingly unpredictable transitions of brain dynamics into the ictal state. The main body of computational research on determining seizure risk has been focused solely on prediction algorithms, which involves a challenging issue of balancing sensitivity and false alarms. There have been some studies on identifying potential biomarkers for seizure forecasting; however, the questions of “What are the true biomarkers for seizure prediction” or even “Is there a valid biomarker for seizure prediction?” are yet to be fully answered. In this paper, we introduce a tool to facilitate the exploration of the potential biomarkers. We confirm using our tool that interictal slowing activities are a promising biomarker for epileptic seizure susceptibility prediction.

Original languageEnglish
Article number721491
Number of pages10
JournalFrontiers in Neurology
Volume12
DOIs
Publication statusPublished - 13 Sep 2021

Keywords

  • Bayesian
  • epileptic seizure forecasting
  • probabilistic programming
  • uncertainty level
  • variational inference

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