Secretion of prolactin in response to serotonin requires an intact hypothalamo-pituitary axis in the ewe

G. B. Thomas; J. T. Cummins; I. J. Clarke

doi:10.1016/0304-3940(88)90444-2

Secretion of prolactin in response to serotonin requires an intact hypothalamo-pituitary axis in the ewe

G. B. Thomas, J. T. Cummins, I. J. Clarke

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

The effects on prolactin secretion and the subsequent site of action of serotonin (5-HT) were examined in ovariectomized hypothalamo-pituitary intact (HP-intact) and ovariectomized hypothalamo-pituitary disconnected (HPD) ewes. The administration of 5 mg per animal of 5-HT increased plasma prolactin concentrations within 20 min by 2- to 3-fold in HP-intact ewes, but had no effect in HPD ewes. Injection of vehicle (saline) did not alter plasma prolactin concentrations in either group. These data indicate that 5-HT is involved in the control of prolactin secretion in sheep and that this action is exerted at the level of the hypothalamus and not directly at the anterior pituitary gland.

Original language	English
Pages (from-to)	143-146
Number of pages	4
Journal	Neuroscience Letters
Volume	85
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(88)90444-2
Publication status	Published - 15 Feb 1988
Externally published	Yes

Keywords

Hypothalamus
Pituitary gland
Prolactin
Serotonin
Sheep

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10.1016/0304-3940(88)90444-2

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abstract = "The effects on prolactin secretion and the subsequent site of action of serotonin (5-HT) were examined in ovariectomized hypothalamo-pituitary intact (HP-intact) and ovariectomized hypothalamo-pituitary disconnected (HPD) ewes. The administration of 5 mg per animal of 5-HT increased plasma prolactin concentrations within 20 min by 2- to 3-fold in HP-intact ewes, but had no effect in HPD ewes. Injection of vehicle (saline) did not alter plasma prolactin concentrations in either group. These data indicate that 5-HT is involved in the control of prolactin secretion in sheep and that this action is exerted at the level of the hypothalamus and not directly at the anterior pituitary gland.",

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AU - Cummins, J. T.

AU - Clarke, I. J.

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AB - The effects on prolactin secretion and the subsequent site of action of serotonin (5-HT) were examined in ovariectomized hypothalamo-pituitary intact (HP-intact) and ovariectomized hypothalamo-pituitary disconnected (HPD) ewes. The administration of 5 mg per animal of 5-HT increased plasma prolactin concentrations within 20 min by 2- to 3-fold in HP-intact ewes, but had no effect in HPD ewes. Injection of vehicle (saline) did not alter plasma prolactin concentrations in either group. These data indicate that 5-HT is involved in the control of prolactin secretion in sheep and that this action is exerted at the level of the hypothalamus and not directly at the anterior pituitary gland.

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KW - Pituitary gland

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KW - Serotonin

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Secretion of prolactin in response to serotonin requires an intact hypothalamo-pituitary axis in the ewe

Abstract

Keywords

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