Secondary cell reprogramming systems: As years go by

Research output: Contribution to journalReview ArticleResearchpeer-review

6 Citations (Scopus)


The groundbreaking discovery of the induced pluripotent stem cells in 2006 [. 1] brought a major paradigm shift in our understanding of the plasticity of differentiated cells. An unprecedented effort has been invested to elucidate the underpinning molecular mechanisms of the dramatic changes in cell properties, using the powerful secondary reprogramming systems (2°RS). This review outlines the key components of the 2°RS, its recent development and applications that have led to a deeper understanding of the 'magic' of induced cell fate changes.

Original languageEnglish
Pages (from-to)534-539
Number of pages6
JournalCurrent Opinion in Genetics and Development
Issue number5
Publication statusPublished - Oct 2013
Externally publishedYes

Cite this