Second to fourth digit ratio (2D: 4D) and prostate cancer risk in the Melbourne Collaborative Cohort Study

D. C. Muller, G. G. Giles, J. T. Manning, J. L. Hopper, D. R. English, Gianluca Severi

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27 Citations (Scopus)

Abstract

Background: The ratio of the lengths of index and ring fingers (2D:4D) is a marker of prenatal exposure to sex hormones, with low 2D:4D being indicative of high prenatal androgen action. Recent studies have reported a strong association between 2D:4D and risk of prostate cancer.Methods:A total of 6258 men participating in the Melbourne Collaborative Cohort Study had 2D:4D assessed. Of these men, we identified 686 incident prostate cancer cases. Hazard ratios (HRs) and confidence intervals (CIs) were estimated for a standard deviation increase in 2D:4D.Results:No association was observed between 2D:4D and prostate cancer risk overall (HRs 1.00; 95% CIs, 0.92-1.08 for right, 0.93-1.08 for left). We observed a weak inverse association between 2D:4D and risk of prostate cancer for age 60, however 95% CIs included unity for all observed ages. Conclusion: Our results are not consistent with an association between 2D:4D and overall prostate cancer risk, but we cannot exclude a weak inverse association between 2D:4D and early onset prostate cancer risk.

Original languageEnglish
Pages (from-to)438-440
Number of pages3
JournalBritish Journal of Cancer
Volume105
Issue number3
DOIs
Publication statusPublished - 26 Jul 2011
Externally publishedYes

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